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Cytoskeletal

Proteins in the cytoplasm that provide structure to a cell are collectively known as the cytoskeleton. In addition to providing structure and protection to individual cells by acting as its musculature and skeleton, the cytoskeleton is involved in a cell’s mobility, division, organization, import and export.

Three categories of proteins comprise the cytoskeleton. These are actin filaments, intermediate filaments, and microtubules. A.G. has several reagents that target unique attributes of the cytoskeletal molecules, our most popular are:

Cytocharasism is a fungal metabolite that inhibits angiogenesis & tumor growth. Enhances PKC-dependent process of secretion. Does not inhibit glucose transport

LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3-Kinase).

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
 

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(+)-Blebbistatin
Product Number: B-1285

Product Name Price Qty
(+)-Blebbistatin - 1xinquire
$0.00
The inactive enantiomer. Also useful as a negative control for the more active enantiomer (-)-Blebbistatin, B-1287. New product inquire for Learn More

(-)-Blebbistatin
Product Number: B-1287

Product Name Price Qty
(-)-Blebbistatin - 1xinquire
$0.00
The active enantiomer that counts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. N Learn More

(±)-Blebbistatin
Product Number: B-1289

Product Name Price Qty
(±)-Blebbistatin - 1xinquire
$0.00
A cell-permeable compound that acts as a selective, potent , and reversible inhibitor of non-moscule myosin II, Inhibits the ATPase and glid Learn More

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Product Number: C-1445

Product Name Price Qty
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide - 1x1 mg
$110.00
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38n Learn More

Antiserum to-Dia1
Product Number: D-1135

Product Name Price Qty
Antiserum to-Dia1 - 1x100 μl
$420.00
Source: Rabbit. Specificity: Raised against a 81 kDa polypeptide corresponding to human Dia1 aa 727-765 (end of FH1 domain) and 1121-1145 (C Learn More

Antiserum to-Dynamin I, (Dyn1) Purified
Product Number: D-1137

Product Name Price Qty
Antiserum to-Dynamin I, (Dyn1) Purified - 1x100 μl
$531.00
Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 633-647 of rat dynamin I. Sequence is completely conserved in mouse and hum Learn More

Antiserum to-Dynamin II, (Dyn2) Purified
Product Number: D-1139

Product Name Price Qty
Antiserum to-Dynamin II, (Dyn2) Purified - 1x100 μl
$525.00
Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 762-781 of human dynamin II. Specificity: Recognizes dynamin II in human, r Learn More

Antiserum to-Dynamin III, (Dyn2) Purified
Product Number: D-1141

Product Name Price Qty
Antiserum to-Dynamin III, (Dyn2) Purified - 1x100 μl
$525.00
Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 623-639 of rat dynamin III (Dyn3). Specificity: Recognizes dynamin III in h Learn More

Antiserum to-Kinesin Motor Protein, Purified
Product Number: K-1056

Product Name Price Qty
Antiserum to-Kinesin Motor Protein, Purified - 1x200 ul
$525.00
Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa residues 780-792 (S780GLTLEPPGDPP792) of mouse KIFC2. Specificity: Detects Learn More

Antiserum to-Kinesin Protein 2, (KIF2), Purified
Product Number: K-1054

Product Name Price Qty
Antiserum to-Kinesin Protein 2, (KIF2), Purified - 1x200 μl
$525.00
Source: Rabbit. Immunogen: Synthetic peptide corresponding to the N-terminal aa residues 1-11 (M1VTSLNEDNES11C) of human and mouse KIF2 with Learn More

Antiserum to-Profilin, Purified
Product Number: P-1215

Product Name Price Qty
Antiserum to-Profilin, Purified - 1x100 μl
$310.00
Source: Rabbit. Immunogen: Porcine platelet profilin. Specificity: Recognizes human, porcine, bovine, mouse, rat, chicken and marsupial prof Learn More

Azaspiracid-1 (AZA-1)
Product Number: A-1700

Product Name Price Qty
Azaspiracid-1 (AZA-1) - 1x1ug
$175.00
Source: Islolated from marine mussel. Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alte Learn More

BAY 11-7082
Product Number: B-1299

Product Name Price Qty
BAY 11-7082 - 1x10 mg
$73.00
BAY 11-7082 - 1x50 mg
$290.00
Potential anti-inflammatory agent. Inhibitor of cytokine induced IκBα phosphorylation, leading to decreased expression of NF-κB and adhes Learn More

Bistheonellide A
Product Number: B-1195

Product Name Price Qty
Bistheonellide A - 1x100 μg
$545.00
Isolated from the marine sponge Theonella sp. Inhibits actin polymerization by forming a 1:2 complex with G-actin. Learn More

BPIQ-I
Product Number: B-1281

Product Name Price Qty
BPIQ-I - 1x1 mg
$200.00
A potent and specific inhibitor of the tyrosine kinase activity of the epidermial growth factor receptor (EGFR). IC₅₀=25 pM. Learn More

BPIQ-II
Product Number: B-1301

Product Name Price Qty
BPIQ-II - 1x1 mg
$200.00
A potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR); IC₅₀=0.008 nM. Blocks gr Learn More

Calcitriol
Product Number: C-1026

Product Name Price Qty
Calcitriol - 1x100 ug
$150.00
Biologically active form of Vitamin D3 in intestinal calcium transport and bone calcium reabsorption. Stimulates Osteoprotegerin. Learn More

Citrinin, Penicillium citrinum
Product Number: C-1109

Product Name Price Qty
Citrinin, Penicillium citrinum - 1x5 mg
$60.00
Citrinin, Penicillium citrinum - 1x10 mg
$105.00
Mycotoxin which induces mitochondrial permeability transition. Also inhibits microtubule polymerization. Learn More

Colchicine
Product Number: C-1164

Product Name Price Qty
Colchicine - 1x1 g
$70.00
Depolymerizes microtubules. Inhibits tubulin polymerization. Induces apoptosis. Learn More

Compound 56
Product Number: C-1535

Product Name Price Qty
Compound 56 - 1x500 ug
$195.00
A potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀=6 pM). Learn More

Cytochalasin A
Product Number: C-1111

Product Name Price Qty
Cytochalasin A - 1x5 mg
$165.00
Cytochalasin A - 1x10 mg
$285.00
A fungal metabolite that acts as an inhibitor of glucose transport and actin polymerization. Learn More

Cytochalasin B, Helminthosporium dematioideum
Product Number: C-1027

Product Name Price Qty
Cytochalasin B, Helminthosporium dematioideum - 1x5 mg
$87.00
Cytochalasin B, Helminthosporium dematioideum - 1x25 mg
$370.00
A fungal metabolite that acts as a microtubule inhibitor. Also induces cellular DNA Fragmentation. Learn More

Cytochalasin C
Product Number: C-1200

Product Name Price Qty
Cytochalasin C - 1x1 mg
$70.00
Cytochalasin C - 1x5 mg
$280.00
A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Learn More

Cytochalasin D, Zygusporium mansonii
Product Number: C-1070

Product Name Price Qty
Cytochalasin D, Zygusporium mansonii - 1x1 mg
$65.00
Cytochalasin D, Zygusporium mansonii - 1x5 mg
$258.00
A fungal metabolite that acts as a potent inhibitor of actin filament and contractile microfilaments. Also shown to protect Hippocampal neur Learn More

Dimethylenastron
Product Number: D-1300

Product Name Price Qty
Dimethylenastron - 1x1 mg
$80.00
Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=200nM) by binding to the mitotic kinesin Eg5. Learn More

Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
Product Number: D-1161

Product Name Price Qty
Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH - 1x5 mg
$245.00
Substrate for MMP-2 and MMP-9. Learn More

FGF-2, Basic, Recombinant, Human
Product Number: F-1158

Product Name Price Qty
FGF-2, Basic, Recombinant, Human - 1x50ug
$195.00

Griseofulvin, Penicillium sp.
Product Number: G-1243

Product Name Price Qty
Griseofulvin, Penicillium sp. - 1x25 mg
$95.00
Griseofulvin, Penicillium sp. - 1x100 mg
$325.00
Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick's group. Griseofulvi Learn More

IL-33, Soluble, Human, Recombinant
Product Number: I-1294

Product Name Price Qty
IL-33, Soluble, Human, Recombinant - 1x10 ug
$187.00
Binds to human ST2. Activates human ST2-dependent NF-κB pathway. Does not activate mouse ST2-dependent NF-κB. Produced in E. coli. Untagge Learn More

IL-33, Soluble, Mouse, Recombinant
Product Number: I-1296

Product Name Price Qty
IL-33, Soluble, Mouse, Recombinant - 1x10 ug
$187.00
Binds to mouse and human ST2. Activates mouse and human ST2-dependent NF-κB pathway. Produced in E. coli. Untagged mouse IL-33 (aa 109-266) Learn More

Latrunculin B, Lutrunculia magnifica
Product Number: L-1057

Product Name Price Qty
Latrunculin B, Lutrunculia magnifica - 1x1 mg
$110.00
Actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fibe Learn More

Leptomycin B, Streptomyces sp.
Product Number: L-1069

Product Name Price Qty
Leptomycin B, Streptomyces sp. - 1x100 ug
$112.00
Antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathw Learn More

MAZ51
Product Number: M-1191

Product Name Price Qty
MAZ51 - 1x2 mg
$90.00
Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt4) (IC50=1uM) Learn More

Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2
Product Number: M-1159

Product Name Price Qty
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 - 1x1 mg
$185.00
Fluorogenic substrate for MMP-3 and MMP-9. Learn More

Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-OH
Product Number: M-1161

Product Name Price Qty
Mca-Pro-Cha-Gly-Nva-His-Ala-Dap(Dnp)-OH - 1x1 mg
$187.00
Fluorogenic substrate for MMP-13. Learn More

Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2
Product Number: M-1163

Product Name Price Qty
Mca-Pro-Leu-Ala-Nva-Dap(Dnp)-Ala-Arg-NH2 - 1x1 mg
$187.00
Fluorogenic substrate for MMP-2. Learn More

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2
Product Number: M-1167

Product Name Price Qty
Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 - 1x1 mg
$187.00
Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 - 1x5 mg
$684.00
Fluorogenic substrate for MMP-2 and MMP-7. Learn More

Monastrol
Product Number: M-1116

Product Name Price Qty
Monastrol - 1x1 mg
$60.00
Monastrol - 1x5 mg
$175.00
Potent, cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50 = 14µM) by binding to the mitotic kinesin Eg5, a mot Learn More

Monoclonal Antibody to β-Catenin (aa27-37)
Product Number: C-1202

Product Name Price Qty
Monoclonal Antibody to β-Catenin (aa27-37) - 1x100 μg
$375.00
Specificity: To nuclear β-Catenin in human, mouse, rat and dog. Clone: 8E4, Isotype: Mouse IgG1. Application: ELISA, ICC, IP, WP. Includes Learn More

Monoclonal Antibody to-BMF (12E10)
Product Number: B-1231

Product Name Price Qty
Monoclonal Antibody to-BMF (12E10) - 1x100 μg
$315.00
Immunogen: Mouse recombinant BMF. Specificity: Recognizes human and mouse BMF. Isotype: Rat IgG1. Application: FC, IP, WB. Learn More

Monoclonal Antibody to-BMF (9G10)
Product Number: B-1233

Product Name Price Qty
Monoclonal Antibody to-BMF (9G10) - 1x100 μg
$315.00
Immunogen: Mouse recombinant Bmf. Specificity: Recognizes human and mouse Bmf. Isotype: Rat IgG2a. Application: FC, IP,WB. Learn More

Monoclonal Antibody to-Laminin-2, α2-chain
Product Number: L-1051

Product Name Price Qty
Monoclonal Antibody to-Laminin-2, α2-chain - 1x100 μg
$375.00
Specificity: Recognizes the mouse laminin-2 (α2-chain); cross reacts with the human protein. No cross-reaction with laminin-1. Clone: 4H8-2 Learn More

Monoclonal Antibody to-Osteoprotegerin, Human, N-terminal (OPG-13)
Product Number: O-1076

Product Name Price Qty
Monoclonal Antibody to-Osteoprotegerin, Human, N-terminal (OPG-13) - 1x100 μg
$625.00
Immunogen: Synthetic peptide corresponding to aa 21-39 of astes protegerin. Specificity: To N-terminus (aa 20-39) of human osteoprotegerin ( Learn More

Monoclonal Antibody to-RANK (Human) 9A725
Product Number: R-1116

Product Name Price Qty
Monoclonal Antibody to-RANK (Human) 9A725 - 1x100 μg
$290.00
Immunogen:Recombinant human RANK (aa326-616). Specificity: The antibody recognizes human RANK. Detects a protein of approx. 66-67 kDa. Clon Learn More

Monoclonal Antibody to-RANKL
Product Number: R-1112

Product Name Price Qty
Monoclonal Antibody to-RANKL - 1x100 μg
$290.00
Specificity: Raised against a fusion protein containing aa 1-317 of mouse RANKL. Detects a 40 kDa band in human and mouse. Clone: 12A668. Is Learn More

Monoclonal Antibody to-VASP (IE 273)
Product Number: V-1049

Product Name Price Qty
Monoclonal Antibody to-VASP (IE 273) - 1x50 μg
$290.00
Immunogen: Purified human vasodilator stimulated posphoprotein (VASP). Specificity: To human VASP. Isotype: Mouse IgG1. Application: WB, IF Learn More

Monoclonal Antibody to-VASP, Activated, Ser239
Product Number: V-1047

Product Name Price Qty
Monoclonal Antibody to-VASP, Activated, Ser239 - 1xPurified 100
$500.00
Monoclonal Antibody to-VASP, Activated, Ser239 - 1xFITC 100
$575.00
Monoclonal Antibody to-VASP, Activated, Ser239 - 1xBiotin 100ug
$575.00
Specificity: Recognizes only Ser239-phosphorylated VASP (a site preferred by cGMP-dependent protein kinase (PKG), but also used by cAMP-depe Learn More

Mouse Monoclonal Antibody-Glial Fibrillary Acidic Protein (GFAP) (2A5)
Product Number: G-1245

Product Name Price Qty
Mouse Monoclonal Antibody-Glial Fibrillary Acidic Protein (GFAP) (2A5) - 1x200 µl
$250.00
DESCRIPTION: GFAP is a member of the intermediate filament protein family which includes desmin, peripherin and vimentin. It is a major prot Learn More

Mouse Monoclonal Antibody-Glial Fibrillary Acidic Protein (GFAP) (2A5) DUPLICATE
Product Number: N/A

Product Name Price Qty
Mouse Monoclonal Antibody-Glial Fibrillary Acidic Protein (GFAP) (2A5) DUPLICATE - 1x200 ul
$0.00
DESCRIPTION: GFAP is a member of the intermediate filament protein family which includes desmin, peripherin and vimentin. It is a major prot Learn More

Mouse Monoclonal Antibody-Neurofilament Alpha-Internexin/NF66 (1D2)
Product Number: N-1211

Product Name Price Qty
Mouse Monoclonal Antibody-Neurofilament Alpha-Internexin/NF66 (1D2) - 1x200 ul
$250.00
DESCRIPTION: Alpha–internexin is an intermediate filament family member expressed during early neuron development and is related to the ne Learn More

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