![Latrunculin B | CAS# [76343-94-7] | Actin filament modulator.Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, Latrunculin B causes stress fibers to shortening and thicken.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_4.gif "Latrunculin B | CAS# [76343-94-7] | Actin filament modulator.Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, Latrunculin B causes stress fibers to shortening and thicken.")
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Product Description
Latrunculin B is an actin filament modulator. 10 to 100-fold more potent than cytochalasins. Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture,
Latrunculin B causes stress fibers to shortening and thicken. Effects N1E-115 cells (mouse neuroblastoma) at starting concentrations of 90 nM (NI43T3 cells, 0.9 μM). Maximum effect at 2.5 μM. Fetal Bovine serum will slowly inactivate. Inhibits cofilin-actin binding (ED50~50 µM).
Latrunculin B causes stress fibers to shortening and thicken. Effects N1E-115 cells (mouse neuroblastoma) at starting concentrations of 90 nM (NI43T3 cells, 0.9 μM). Maximum effect at 2.5 μM. Fetal Bovine serum will slowly inactivate. Inhibits cofilin-actin binding (ED50~50 µM).
Attached is a published reference from researchers who have used our Latrunculin B product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
http://ajpcell.physiology.org/content/295/3/C768.full.pdf+html
Additional Information
COA Documentation: |
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| Product Number | L-1057 |
| CAS # | CAS [76343-94-7] |
| Chemical Name | Isolated from Lutrunculia magnifica |
| Chemical Formula | C20H29NO5S |
| Appearance | Lyophilized Solid |
| Merck Index | Merck Index: 14: 5378 |
| Molecular Weight | M.W. 395.5 |
| Purity | Purity: >98% |
| Solubility | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| Storage Temp | -20°C |
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![Latrunculin B | CAS# [76343-94-7] | Actin filament modulator.Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, Latrunculin B causes stress fibers to shortening and thicken.](http://www.agscientific.com/media/catalog/product/cache/1/image/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_lg_1.gif "Latrunculin B | CAS# [76343-94-7] | Actin filament modulator.Where cytochalasin D induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, Latrunculin B causes stress fibers to shortening and thicken.")
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