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Inhibitors

Invasive proteases can contaminate research samples and slow or halt research progress, rendering time-consuming and expensive work useless. Protease inhibitor cocktails are a unique series of enzyme inhibitors that knock out specific proteases to avoid peptide bond hydrolysis and subsequent protein destruction. A.G. Scientific maintains a large selection of standard inhibitor cocktails in stock, as well as the ability to prepare custom formulations, our most popular are:

Protease Inhibitor Cocktail III is a specially formulated cocktail of six protease inhibitors with broad specificity for the inhibition of aspartic, cysteine and serine proteases as well as aminopeptidases.

Protease Inhibitor Cocktail IV specially formulated cocktail of four protease inhibitors with broad specificity for the inhibition of serine, cysteine, aspartic and metallo-proteases. 

Bestatin is an aminopeptidase inhibitor.

Leupeptin a reversible inhibitor of serine and cysteine proteases. Often used for the inhibition of plasmin, trypsin, papain, kallikrein and cathepsin B.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
 

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(+)-Aphidicolin, Nigrospora oryzae
Product Number: A-1026

Product Name Price Qty
(+)-Aphidicolin, Nigrospora oryzae - 1x1 mg
$55.00
(+)-Aphidicolin, Nigrospora oryzae - 1x5 mg
$185.00
(+)-Aphidicolin, Nigrospora oryzae - 1x25 mg
$670.00
Reversible Inhibitor of eukaryotic nuclear DNA replication. Learn More

(+)-Blebbistatin
Product Number: B-1285

Product Name Price Qty
(+)-Blebbistatin - 1xinquire
$0.00
The inactive enantiomer. Also useful as a negative control for the more active enantiomer (-)-Blebbistatin, B-1287. New product inquire for Learn More

(+)-Pyripyropene A, Aspergillus fumigatus
Product Number: P-1655

Product Name Price Qty
(+)-Pyripyropene A, Aspergillus fumigatus - 1x500 µg
$190.00
Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Learn More

(-)-Arctigenin, Arctium lappa
Product Number: A-1308

Product Name Price Qty
(-)-Arctigenin, Arctium lappa - 1x25 mg
$70.00
Lignan derivative, which shows anti-tumor, anti-inflammatory, immunomodulatory and neuroprotective activities. Down-regulates anti-apoptotic Learn More

(-)-Arctiin, Arctium lappa
Product Number: A-1306

Product Name Price Qty
(-)-Arctiin, Arctium lappa - 1x25 mg
$60.00
Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA Learn More

(-)-Blebbistatin
Product Number: B-1287

Product Name Price Qty
(-)-Blebbistatin - 1xinquire
$0.00
The active enantiomer that counts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. N Learn More

(2)-Imino-4-Methylpiperidine.Acetate Salt
Product Number: I-1009

Product Name Price Qty
(2)-Imino-4-Methylpiperidine.Acetate Salt - 1x25 mg
$90.00
A potent and selective inhibitor of inducible Nitric Oxide Synthase, iNOS / NOS II (IC50= 0.1 mM). Learn More

(E)-Capsaicin
Product Number: C-1095

Product Name Price Qty
(E)-Capsaicin - 1x200 mg
$90.00
(E)-Capsaicin - 1x1 g
$360.00
Excitant of peripheral sensory nerves endings. Learn More

(R,S)-Rolipram
Product Number: R-1012

Product Name Price Qty
(R,S)-Rolipram - 1x5 mg
$35.00
(R,S)-Rolipram - 1x50 mg
$165.00
Selective inhibitor of cAMP-specific phophodiesterase, PDE IV. Learn More

(S)-Roscovitine
Product Number: R-2022

Product Name Price Qty
(S)-Roscovitine - 1x1 mg
$40.00
the (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (#R1016). Potently inhibits p34cdc2/cyclin B kinase (IC Learn More

(±)-Blebbistatin
Product Number: B-1289

Product Name Price Qty
(±)-Blebbistatin - 1xinquire
$0.00
A cell-permeable compound that acts as a selective, potent , and reversible inhibitor of non-moscule myosin II, Inhibits the ATPase and glid Learn More

(±)-Thalidomide
Product Number: T-1020

Product Name Price Qty
(±)-Thalidomide - 1x100 mg
$102.00
(±)-Thalidomide - 1x500 mg
$410.00
Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. Learn More

1-Azakenpaullone
Product Number: A-1312

Product Name Price Qty
1-Azakenpaullone - 1x1 mg
$95.00
1-Azakenpaullone - 1x5 mg
$380.00
Analog of kenpaullone acting as a potent and ATP-competitive inhibitor of GSK-3β (IC50=18nM). Displays ~100-200 fold greater selectivity on Learn More

1-D-3-Deoxy-phophatidylinositol
Product Number: D-1113

Product Name Price Qty
1-D-3-Deoxy-phophatidylinositol - 1x100 μg
$30.00
1-D-3-Deoxy-phophatidylinositol - 1x1 mg
$150.00
Antimetabolite of phosphatidylinositol-3-phosphate. An inhibitor of cancer cell colony formation. Learn More

1-Deoxymannojirimycin.HCl
Product Number: D-1155

Product Name Price Qty
1-Deoxymannojirimycin.HCl - 1x1 mg
$29.00
1-Deoxymannojirimycin.HCl - 1x5 mg
$120.00
Potent inhibitor of a-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-li Learn More

1-Deoxynojirimycin
Product Number: D-1157

Product Name Price Qty
1-Deoxynojirimycin - 1x1 mg
$31.00
1-Deoxynojirimycin - 1x5 mg
$112.00
Antibiotic which acts as an inhibitor of mammalian glucosidases I and II. Learn More

1-Elaidylphosphocholine (C18:1, trans)
Product Number: E-1110

Product Name Price Qty
1-Elaidylphosphocholine (C18:1, trans) - 1x250 mg
$80.00
1-Elaidylphosphocholine (C18:1, trans) - 1x1 g
$240.00
Alkylphosphocholine which acts as an anti-tumor agent. Learn More

1-Octadecylphosphocholine, Synthetic
Product Number: O-1070

Product Name Price Qty
1-Octadecylphosphocholine, Synthetic - 1x250 mg
$45.00
1-Octadecylphosphocholine, Synthetic - 1x1 g
$135.00
Alkylphosphocholine which acts as an anti-tumor agent. Learn More

10-Hydroxycamptothecin
Product Number: H-1132

Product Name Price Qty
10-Hydroxycamptothecin - 1x inquire
$0.00
A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. Inquire for pricing and lead time. Learn More

10z-Hymenialdisine
Product Number: H-1150

Product Name Price Qty
10z-Hymenialdisine - 1x500 μg
$185.00
Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cycli Learn More

1400W
Product Number: W-1020

Product Name Price Qty
1400W - 1x5 mg
$48.00
1400W - 1x25 mg
$188.00
A highly selective inhibitor of inducible Nitric Oxide Synthase (iNOS). Learn More

17-AAG
Product Number: A-1256

Product Name Price Qty
17-AAG - 1x500 μg
$50.00
17-AAG - 1x1 mg
$70.00
17-AAG - 1x5mg
$185.00
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Learn More

17DMAG
Product Number: A-1298

Product Name Price Qty
17DMAG - 1x1mg
$70.00
17DMAG - 1x5 mg
$185.00
A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Gelda Learn More

2-Phthalimidino-glutaric acid
Product Number: P-1187

Product Name Price Qty
2-Phthalimidino-glutaric acid - 1x5 mg
$60.00
Stable analog of Thalidomide with increased anti-tumor potency. Learn More

3-Bromo-7-Nitroindazole
Product Number: B-1001

Product Name Price Qty
3-Bromo-7-Nitroindazole - 1x25 mg
$50.00
3-Bromo-7-Nitroindazole - 1x50 mg
$80.00
A potent inhibitor of rat cerebellar Nitric Oxide Synthase (NOS). More potent inhibitor than 7-nitroindazole. Learn More

3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata
Product Number: B-1265

Product Name Price Qty
3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata - 1x5 mg
$130.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topo Learn More

3-O-Acetyl-beta-boswellic acid, Boswellia sp.
Product Number: B-1263

Product Name Price Qty
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x1 mg
$45.00
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x5 mg
$178.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and top Learn More

3-O-OMe-GlcNAc
Product Number: M-1205

Product Name Price Qty
3-O-OMe-GlcNAc - 1x5 mg
$192.00
Inhibitor of N-acetylglucosamine kinase (Ki=17µM) and N-acetylmannosamine kinase (Ki=80µM). Learn More

5-Iodo-indirubin-3'-monoxime
Product Number: I-1308

Product Name Price Qty
5-Iodo-indirubin-3'-monoxime - 1x1 mg
$90.00
Potent inhibitor of GSK-3Beta (IC50=9nM). Also inhibits CDK1/cyclin B (IC50=25nM) and CDK5/p25 (IC50=20nM) by binding to the ATP-binding poc Learn More

5-Iodotubercidin, Itu
Product Number: I-1005

Product Name Price Qty
5-Iodotubercidin, Itu - 1x1 mg
$113.00
5-Iodotubercidin, Itu - 1x5 mg
$450.00
A potent and specific inhibitor of ERK2. Also adenosine kinase inhibitor. Learn More

6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Product Number: C-1445

Product Name Price Qty
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide - 1x1 mg
$110.00
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38n Learn More

6BIO , GSK-3 Inhibitor
Product Number: G-1247

Product Name Price Qty
6BIO , GSK-3 Inhibitor - 1x1 mg
$50.00
A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Inhibition of GSK by Learn More

7-Amino-Actinomycin D
Product Number: A-1132

Product Name Price Qty
7-Amino-Actinomycin D - 1x1 mg
$70.00
7-Amino-Actinomycin D - 1x5 mg
$240.00
Fluorescent DNA Stain. Binds Single stranded DNA. Useful tool in determining apoptosis. Learn More

7-Nitroindazole
Product Number: N-1011

Product Name Price Qty
7-Nitroindazole - 1x100 mg
$50.00
An inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. Learn More

7-Nitroindazole.Monosodium Salt
Product Number: N-1013

Product Name Price Qty
7-Nitroindazole.Monosodium Salt - 1x25 mg
$75.00
7-Nitroindazole.Monosodium Salt - 1x100 mg
$225.00
A readily soluble inhibitor of Nitric Oxide Synthase (NOS). It has a selectivity for brain NOS. Learn More

8-iso-Prostaglandin F2α
Product Number: P-1207

Product Name Price Qty
8-iso-Prostaglandin F2α - 1x1 mg
$120.00
Potent vasoconstrictor in rat lung and kidney where its effects seem to be mediated through thromboxane receptors. However, evidence exists Learn More

8-Isopentenylnaringenin from hop Humulus lupulus L.
Product Number: I-1298

Product Name Price Qty
8-Isopentenylnaringenin from hop Humulus lupulus L. - 1x5 mg
$162.00
Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent in vitro and in vivo angiogenesis inhibitor. Chemoprevent Learn More

9-Cyanopaullone
Product Number: C-1205

Product Name Price Qty
9-Cyanopaullone - 1x1 mg
$70.00
9-Cyanopaullone - 1x5 mg
$275.00
Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. 9-cyanopaullone is a potent inhibitor of CDK1/ Learn More

Ac-ESMD-CHO
Product Number: G-1073

Product Name Price Qty
Ac-ESMD-CHO - 1x1 mg
$83.00
Ac-ESMD-CHO - 1x5 mg
$320.00
Reversible Inhibitor of granzyme B and caspase-8. Inhibits also caspase-6 and -10. This peptide sequence corresponds to one of the cleavage Learn More

Ac-IETD-CHO
Product Number: G-1071

Product Name Price Qty
Ac-IETD-CHO - 1x1 mg
$62.00
Ac-IETD-CHO - 1x5 mg
$240.00
Reversible inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10. Peptide content: 70-90% Learn More

ACRP30, Soluble (Mouse) (Recombinant)
Product Number: A-1274

Product Name Price Qty
ACRP30, Soluble (Mouse) (Recombinant) - 1x50 μg
$330.00
Source: Produced in HEK 293. Mouse ACRP30 (aa 18-247) fused at the N-terminus to a linker peptide (8 aa) and a FLAG tag. Reconstitution: Rec Learn More

Actinomycin D, Streptomyces sp.
Product Number: A-1022

Product Name Price Qty
Actinomycin D, Streptomyces sp. - 1x5 mg
$45.00
Actinomycin D, Streptomyces sp. - 1x10 mg
$70.00
Actinomycin D, Streptomyces sp. - 1x25 mg
$155.00
Actinomycin D, Streptomyces sp. - 1x100 mg
$455.00
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymera Learn More

Actinonin
Product Number: A-1120

Product Name Price Qty
Actinonin - 1x5mg
$90.00
Antibiotic that demonstrates anti-tumor activity. Also unique antibacterial agent. Inhibitor of leucine aminopeptidase. Learn More

Adriamycin hydrochloride, Streptomyces peucetius
Product Number: A-1434

Product Name Price Qty
Adriamycin hydrochloride, Streptomyces peucetius - 1x25 mg
$180.00
Adriamycin hydrochloride, Streptomyces peucetius - 1x100 mg
$615.00
Adriamycin hydrochloride has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological pr Learn More

Adriamycin, Streptomyces peucetius
Product Number: A-1442

Product Name Price Qty
Adriamycin, Streptomyces peucetius - 1x25 mg
$200.00
Adriamycin, Streptomyces peucetius - 1x100 mg
$695.00
Adriamycin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces spec Learn More

AEBSF.hydrochloride
Product Number: A-1018

Product Name Price Qty
AEBSF.hydrochloride - 1x50 mg
$40.00
AEBSF.hydrochloride - 1x250 mg
$142.00
AEBSF.hydrochloride - 1x1 g
$345.00
Specific irreversible inhibitor of serine proteases, such as thrombin, plasmin, kallikrein, chymotrypsin, and trypsin. It is a non- toxic al Learn More

AG 1007
Product Number: A-1180

Product Name Price Qty
AG 1007 - 1x1 mg
$50.00
AG 1007 - 1x5 mg
$148.00

AG 1024
Product Number: A-1178

Product Name Price Qty
AG 1024 - 1x1 mg
$65.00
AG 1024 - 1x5 mg
$248.00
An inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Learn More

AG 1112
Product Number: A-1176

Product Name Price Qty
AG 1112 - 1x1 mg
$50.00
AG 1112 - 1x5 mg
$148.00

AG 126
Product Number: A-1208

Product Name Price Qty
AG 126 - 1x5 mg
$75.00

Reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM.  At 100uM does not inhibi Learn More

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