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Cycloheximide - 1x5 g$75.00
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Product Description
An anti-neoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis.
Potent anti-tumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Attached are a few published references from researchers who have used our Actinomycin D product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
http://www.jbc.org/content/280/14/14130.full.pdf+html
Seeking published researchers utilizing our Actinomycin D product? Hit the hot link for the full paper.
1. Heat Stress Cognate 70 Host Protein as a Potential Drug Target against Drug Resistance in Hepatitis B Virus, Yu-Ping Wang, Fei Liu, et al,May 2010; 54: 2070 - 2077.
2. Respiratory Syncytial Virus Inhibits Lung Epithelial Na+ Channels by Up-regulating Inducible Nitric-oxide Synthase, Weifeng Song, Gang Liu, et al, Mar 2009; 284: 7294 - 7306.
3. The DNA/RNA-Binding Protein, Translin, Binds microRNA122a and Increases Its In Vivo Stability, Zuoren Yu and Norman B, et al, Sep 2008; 29: 572 - 579.
4. Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2, Rowan W. Balzary andThomas M, et al, May 2006; 317: 806 - 812.
5. A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor- Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia, Tzu-Hsuan Huang and Sherie L. Morrison, et al, Mar 2006; 316: 983 - 991.
6. Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, HOSPHATIDYLINOSITOL 3-, AND JNK KINASES, Anthony M. Vertino, Craig M. Bula, et al, Apr 2005; 280: 14130 - 14137.
Potent anti-tumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Attached are a few published references from researchers who have used our Actinomycin D product. We respectfully thank them for their trust in our product. Inquire for a full reference list.
http://aac.asm.org/content/54/5/2070.full.pdf+html
http://jpet.aspetjournals.org/content/316/3/983.full.pdf+html
http://jpet.aspetjournals.org/content/317/2/806.full.pdf+html
http://www.jbc.org/content/280/14/14130.full.pdf+html
Seeking published researchers utilizing our Actinomycin D product? Hit the hot link for the full paper.1. Heat Stress Cognate 70 Host Protein as a Potential Drug Target against Drug Resistance in Hepatitis B Virus, Yu-Ping Wang, Fei Liu, et al,May 2010; 54: 2070 - 2077.
2. Respiratory Syncytial Virus Inhibits Lung Epithelial Na+ Channels by Up-regulating Inducible Nitric-oxide Synthase, Weifeng Song, Gang Liu, et al, Mar 2009; 284: 7294 - 7306.
3. The DNA/RNA-Binding Protein, Translin, Binds microRNA122a and Increases Its In Vivo Stability, Zuoren Yu and Norman B, et al, Sep 2008; 29: 572 - 579.
4. Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2, Rowan W. Balzary andThomas M, et al, May 2006; 317: 806 - 812.
5. A Trimeric Anti-HER2/neu ScFv and Tumor Necrosis Factor- Fusion Protein Induces HER2/neu Signaling and Facilitates Repair of Injured Epithelia, Tzu-Hsuan Huang and Sherie L. Morrison, et al, Mar 2006; 316: 983 - 991.
6. Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, HOSPHATIDYLINOSITOL 3-, AND JNK KINASES, Anthony M. Vertino, Craig M. Bula, et al, Apr 2005; 280: 14130 - 14137.
Additional Information
MSDS Documentation:COA Documentation: |
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| Product Number | A-1022 |
| CAS # | CAS [50-76-0] |
| Chemical Name | Isolated from Streptomyces sp. |
| Chemical Formula | C62H86N12O16 |
| Alternative Name | Actinomycin IV, Actinomycin C1, Dactinomycin |
| Appearance | Red to orange powder |
| Merck Index | Merck Index: 12.2867.1996 |
| Molecular Weight | M.W. 1255.42 |
| Purity | Purity: >98% |
| Solubility | Soluble in DMSO: 1mg/mL, ethanol. |
| Storage Temp | +4°C |
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