![IM-54 | Cell Permeable Necrosis inhibitor | CAS [861891-50-1] |, Novel apoptotic, necrotic, Necroptotic inhibitors from A.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/f/i/file_2_32.jpg "IM-54 | Cell Permeable Necrosis inhibitor | CAS [861891-50-1] |, Novel apoptotic, necrotic, Necroptotic inhibitors from A.G. Scientific.")
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Product Description
IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase 1.
K. Dodo, et al.; Bioorg. Med. Chem. LEtt. 15, 3114 (2005).
K. Dodo, et al.; Bioorg. Med. Chem. LEtt. 15, 3114 (2005).
Additional Information
| Product Number | I-1322 |
| CAS # | 861891-50-1 |
| Chemical Name | [2-(1H-Indol-3-yl)-3-pentylamino-maleimide] |
| Chemical Formula | C19H23N3O2 |
| Appearance | Yellow powder |
| Purity | ≥98% (HPLC) |
| Solubility | Soluble in DMSO (100mg/ml), dichloomethane, 100% |
| Storage Temp | -20°C |
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![IM-54 | Cell Permeable Necrosis inhibitor | CAS [861891-50-1]|, Novel apoptotic, necrotic, Necroptotic inhibitors from A.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/image/5e06319eda06f020e43594a9c230972d/f/i/file_2_29.gif "IM-54 | Cell Permeable Necrosis inhibitor | CAS [861891-50-1]|, Novel apoptotic, necrotic, Necroptotic inhibitors from A.G. Scientific.")
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