Image courtesy of Public Library of Science publication. Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein from researchers at Center for Hepatitis Research, University of Texas Medical Branch, Galveston, Texas, USA, Department of Microbiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA, Department of Molecular Genetics and Microbiology, Institute for Cellular and Molecular Biology, University of Texas Austin, Austin, Texas, USA, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA. Nuclear phospho-pRb expression was partially restored by treatment with epoxomicin in Huh-7.5 Human Hepatoma Cells.
A.G. Scientific: A leader in proteasomes
Proteasomes are large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytomplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
