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Proteasomes

Proteasomes

AG Scientific: A leader in proteasomes

Proteasomes are large protein complexes inside all eukaryotes and archaea, as well as in some bacteria. In eukaryotes, they are located in the nucleus and the cytomplasm. The main function of the proteasome is to degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.

Enzymes that carry out such reactions are called proteases. Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.

AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

FREE REVIEW ARTICLES

Heterogeneous Cardiac Proteasomes: Mandated by Diverse Substrates?, Sarah B. Scruggs, Peipei Ping, et al. Heterogeneous Cardiac Proteasomes: Mandated by Diverse Substrates? Physiology, 2011; 26: 106 - 114.

Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics, Sarah B. Scruggs, Nobel C. Zong, et al. Post-translational modification of cardiac proteasomes: functional delineation enabled by proteomics. Am J Physiol Heart Circ Physiol, 2012; 303: H9 - H18.

Functional alterations of cardiac proteasomes under physiological and pathological conditions, Osamu Tsukamoto, Tetsuo Minamino, et al. Functional alterations of cardiac proteasomes under physiological and pathological conditions. Cardiovasc Res, 2010; 85: 339 - 346.

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Product Number	P-1520
CAS #	[5144-89-8]
Chemical Formula	C₁₂H₈N₂.H₂₀
Appearance	White Solid
Molecular Weight	M.W. 198.22
Purity	Purity: >99%
Solubility	Soluble in DMSO (100mg/ml), EtOH (25mg/ml), H20 (3mg/ml). Effective concentration 1-10mM.
Storage Temp	ROOM TEMP

COA Documentation: P-1520, B1073 1, 10-Phenanthroline. Monohydrate Product Number: P-1520
Price	Price	Qty	Add to Cart
1x500 mg	$40.00

Product Number	P-1551
Appearance	Lyophilized
Solubility	Soluble in 1ml H₂0 to obtain 1 ml stock solution
Storage Temp	-20C

MSDS Documentation: P-1551, PIA, MSDS COA Documentation: P-1551, B1579 P-1551, C1097 A custom cocktail for optimum inhibition of calciuPIA 100x Protease Inhbitor A Cocktail \| AG Scientific Product Number: P-1551
Price	Price	Qty	Add to Cart
1x1 vial	$45.00

Product Number	S-1090
Appearance	Liquid
Storage Temp	-20°C

COA Documentation: S-1090, A9414, r01 Antiserum to-NEDD8 Product Number: S-1090
Price	Price	Qty	Add to Cart
1x200 μl	$325.00

Product Number	S-1086
Appearance	Liquid. 200 ul Rabbit Antiserum in 50% Glycerol containing 1mM Sodium Azide.
Storage Temp	-20°C

Antiserum to-SUMO-1/Sentrin-1, Human Product Number: S-1086
Price	Price	Qty	Add to Cart
1x200 μl	$315.00

Product Number	S-1092
Appearance	Formulation: Liquid. 50 mg in 50 mM Tris HCL, pH 7.5, 100 mM NaCl, 19% BSA, 10% Glycerol.
Storage Temp	-20°C

COA Documentation: S-1092, A7400 Antiserum to-Ubc9, Human, Purified Product Number: S-1092
Price	Price	Qty	Add to Cart
1x50 μg	$225.00

Product Number	C-1259
CAS #	CAS [136632-32-1]
Chemical Name	N-Acetyl-Leu-Leu-methioninal
Chemical Formula	C₁₉H₃₅N₃O₄S
Alternative Name	Ac-Leu-Leu-Met-CHO, ALLM
Appearance	White Powder
Molecular Weight	M.W. 401.6
Purity	Purity: ≥95%
Solubility	Soluble in DMSO (25mg/ml), Ethanol (25mg/ml).
Storage Temp	-20°C

COA Documentation: C-1259, A9041A Calpain Inhibitor II Product Number: C-1259
Price	Price	Qty	Add to Cart
1x5 mg	$85.00
1x25 mg	$330.00

Product Number	C-2262
CAS #	34157-83-0
Chemical Name	(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Chemical Formula	C₂₉H₃₈O₄
Appearance	Red solid
Molecular Weight	450.61
Purity	≥98% by TLC
Solubility	DMSO (45 mg/ml) or Ethanol (30 mg/ml)
Storage Temp	-20°C

Celastrol Product Number: C-2262
Price	Price	Qty	Add to Cart
1x5 mg	$60.00
1x25 mg	$230.00

Product Number	L-1055
CAS #	CAS [155975-72-7]
Chemical Formula	C₁₀H₁₅NO₄
Alternative Name	Omualide
Appearance	White Solid
Molecular Weight	M.W. 213.2
Purity	Purity: >95%
Solubility	Soluble and stable in DMSO (25mg/ml), or acetonitrile (MeCN).
Storage Temp	-20°C

COA Documentation: L-1055, B1186 L-1055, B1250 L-1055, C1343 clasto-Lactacystin β-lactone, Synthetic Product Number: L-1055
Price	Price	Qty	Add to Cart
1x100 μg	$205.00

Product Number	E-1098
CAS #	CAS [134381-21-8]
Chemical Formula	C₂₈H₅₀N₄O₇
Appearance	White Solid
Merck Index	Merck: 14:3630
Molecular Weight	M.W. 554.7
Purity	Purity: ≥95%
Solubility	Soluble in DMSO or Dichloromethane:methanol (9:1). Insoluble in Water.
Storage Temp	-20°C

COA Documentation: E-1098, C1052 E-1098, C1225 Epoxomicin, Synthetic Product Number: E-1098
Price	Price	Qty	Add to Cart
1x100 µg	$195.00

Product Number	G-1231
CAS #	CAS [142880-36-2]
Chemical Formula	C₂₀H₂₈N₄O₄
Appearance	White to off-white solid
Molecular Weight	M.W. 388.5
Purity	Purity: ≥95%
Solubility	DMSO, or 100% Ethanol
Storage Temp	-20°C

GM6001 Product Number: G-1231
Price	Price	Qty	Add to Cart
1x1 mg	$95.00

Product Number	L-1147
CAS #	CAS [133343-34-7]
Chemical Formula	C₁₅H₂₄N₂O₇S
Alternative Name	Lactacystin \| CAS#33343-34-7 \| Inhibits Proteosome
Appearance	White Solid
Molecular Weight	M.W. 376.4
Purity	Purity: >98%
Solubility	Lactacystin is soluble DMSO (20 mg/ml), DMF, Acetonitrile, Ethanol. Lactacystin is also soluble in water (10 mg/ml) & aqueous buffers but subject to hydrolysis.
Storage Temp	-20°C

MSDS Documentation: L-1147, Lactacystin, MSDS, EU and US certified COA Documentation: L-1147, C1039 L-1147, B1977 L-1147, C1124 Lactacystin Product Number: L-1147
Price	Price	Qty	Add to Cart
1x200 ug	$125.00
1x1 mg	$540.00

Product Number	L-1165
CAS #	CAS [103476-89-7]
Chemical Name	Ac-Leu-Leu-Arginal
Chemical Formula	C₂₀H₃₈N₆O₄.0.5 H₂SO₄
Alternative Name	Ac-Leu-Leu-Arginal, Leupeptin
Appearance	White Solid
Molecular Weight	M.W. 475.6
Purity	Purity: Three tautomeric isomers in solution
Solubility	Soluble in H20 (50mg/ml). Effective concentration 10-100uM
Storage Temp	-20°C

MSDS Documentation: L-1165, MSDS.pdf COA Documentation: L-1165, C1165E L-1165, D1017A L-1165, C1165D L-1165, D1017 Leupeptin, Hemisulfate Product Number: L-1165
Price	Price	Qty	Add to Cart
1x5 mg	$22.00
1x25 mg	$93.50
1x100 mg	$330.00

Product Number	M-1155
Chemical Name	Z-Leu-Leu-Nva-aldehyde; Z-LL-Nva-CHO
Chemical Formula	C₂₅H₃₉N₃O₅
Appearance	White Lyophilized Powder
Molecular Weight	M.W. 461.6
Purity	Purity: >99%
Solubility	Soluble in DMSO.
Storage Temp	-20°C

COA Documentation: M-1155, A7447B M-1155, A8303 M-1155,A6010 MG-115 Product Number: M-1155
Price	Price	Qty	Add to Cart
1x1 mg	$49.00
1x5 mg	$120.00

Product Number	M-1157
CAS #	CAS[133407-82-6]
Chemical Name	Z-Leu-Leu-Leu-aldehyde; Z-LLL-CHO
Chemical Formula	C₂₆H₄₁N₃O₅
Alternative Name	Z-LLL-CHO
Appearance	White Lyophilized Powder
Molecular Weight	M.W. 475.6
Purity	Purity: >95%
Solubility	Soluble in DMSO.
Storage Temp	-20°C

MSDS Documentation: M-1157, MG-132, MSDS COA Documentation: M-1157, C1187 M-1157, C1227 M-1157, C1227A M-1157, D1060 MG-132 Product Number: M-1157
Price	Price	Qty	Add to Cart
1x1 mg	$15.00
1x5 mg	$55.00

Product Number	Z-1003
Chemical Formula	C₂₅H₄₂BN₃O₆
Alternative Name	MG-262, Proteasome Inhibitor III, Z-LLL-B(OH)2 , Z-Leu-Leu-Leu-B(OH)2
Molecular Weight	M.W. 491.44
Purity	Purity: >98%
Solubility	Soluble in DMSO.
Storage Temp	-20°C

COA Documentation: Z-1003, B1752 MG-262 \| Z-Leu-Leu-Leu-B(OH)2 \| Potent, Selective, Reversible Proteosome Inhibitor Product Number: Z-1003
Price	Price	Qty	Add to Cart
1x100 ug	$210.00

Product Number	P-1149
Chemical Name	Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Chemical Formula	C₃₂H₅₀N₄O₈
Alternative Name	Z-Ile-Glu(OtBu)-Ala-Leu-CHO; Z-IE(OtBu)AL-CHO
Appearance	White powder.
Molecular Weight	M.W. 618.8
Purity	Purity: ≥95%
Solubility	Soluble in 100% ethanol (30mg/ml), DMSO (30mg/ml) or methanol.
Storage Temp	-20°C

COA Documentation: P-1149, C1068 Proteasome Inhibitor I (aldehyde) Product Number: P-1149
Price	Price	Qty	Add to Cart
1x1 mg	$28.00
1x5 mg	$110.00

Product Number	P-1159
Chemical Name	Z-Leu-Leu-Leu-AMC
Chemical Formula	C₃₆H₄₈N₄O₇
Alternative Name	Z-Leu-Leu-Leu-AMC; Z-LLL-AMC
Appearance	White lyophilized powder.
Molecular Weight	M.W.648.8
Purity	Purity:≥98%
Solubility	Soluble in DMSO.
Storage Temp	-20°C

Proteasome Substrate I (Fluorogenic) Product Number: P-1159
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1x1 mg	$22.00
1x5 mg	$82.00

Product Number	P-1161
Chemical Name	Z-Leu-Leu-Glu-AMC
Chemical Formula	C₃₅H₄₄N₄O₉
Alternative Name	Z-LLE-AMC
Appearance	Off white, Lyophilized.
Molecular Weight	M.W.664.8
Purity	Purity: >95%
Solubility	Soluble in DMF.
Storage Temp	-20°C

COA Documentation: P-1161, A6154C Proteasome Substrate II (Fluorogenic) Product Number: P-1161
Price	Price	Qty	Add to Cart
1x5 mg	$143.00

Product Number	P-1163
Chemical Name	Suc-Leu-Leu-Val-Tyr-AMC
Alternative Name	Suc-Leu-Leu-Val-Tyr-AMC; Z-LLVY-AMC; Calpain Substrate (Fluorogenic)
Appearance	White to off-white lyophilized powder.
Molecular Weight	M.W.762.9
Purity	Purity: ≥98% (HPLC)
Solubility	Soluble in DMSO.
Storage Temp	-20°C

COA Documentation: P-1163, B1252 P-1163, A9894 Proteasome Substrate III (Fluorogenic) Product Number: P-1163
Price	Price	Qty	Add to Cart
1x5 mg	$77.00

Product Number	P-1165
Chemical Name	Z-Val-Lys-Met-AMC; Z-VKM-AMC
Purity	Purity: >95%

Proteasome Substrate IV (Fluorogenic) Product Number: P-1165
Price	Price	Qty	Add to Cart
1x1 mg	$25.00
1x5 mg	$98.00

Product Number	P-1265
CAS #	CAS [39450-01-6]
Appearance	White lyophilized solid
Molecular Weight	M.W. 28,500
Purity	Activity: >30 units/mg solid
Storage Temp	+4ºC

MSDS Documentation: P-1265, Proteinase K, MSDS COA Documentation: P-1265, C1363 P-1265, C1363B P-1265, D1044 P-1265, D1044A Proteinase K Product Number: P-1265
Price	Price	Qty	Add to Cart
1x50 mg	$50.00
1x100 mg	$65.00
1x1 g	$475.00

Product Number	C-1602
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H2O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

COA Documentation: C-1602, D1041 ProteomeStore™ Brain, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1602
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	C-1604
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

COA Documentation: C-1604, B1124 ProteomeStore™ Heart, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1604
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	C-1606
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

ProteomeStore™ Kidney, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1606
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

ProteomeStore™ Liver, Cytosolic Proteins, Undenatured, Mouse, Swiss Webster Product Number: C-1608
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

ProteomeStore™ Liver, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1610
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

ProteomeStore™ Lung, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1612
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

ProteomeStore™ Spleen, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1614
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

ProteomeStore™ Urinary Protein Concentrate, Undenatured, Human, Male Product Number: U-1098
Price	Price	Qty	Add to Cart
1x1 mg	$100.00

PS-341 Product Number: P-2408
Price	Price	Qty	Add to Cart
1x1 mg	$55.00
1x5 mg	$190.00

Sirtinol Product Number: S-1142
Price	Price	Qty	Add to Cart
0x	$0.00
1x1 mg	$32.00
1x5 mg	$105.00

SUMO-1/Sentrin-1 (1-101), Human, Recombinant, Product Number: S-1082
Price	Price	Qty	Add to Cart
1x250 μg	$245.00

SUMO-1/Sentrin-1 (1-97), Human, Recombinant Product Number: S-1084
Price	Price	Qty	Add to Cart
1x500 μg	$290.00

TCEP.HCl Product Number: T-1180
Price	Price	Qty	Add to Cart
1x1 g	$44.00
1x5 g	$195.00

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Proteasomes

AG Scientific: A leader in proteasomes

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Product Number	C-1608
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

Product Number	C-1610
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

Product Number	C-1612
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

Product Number	C-1614
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

Product Number	U-1098
Appearance	Lyophilized from 5% sucrose; 10 mM sodium phosphate, pH 7.0; 150 mM NaCl; 1 mM EDTA; 1 mM 2-mercaptoethanol at a protein concentration of 1 mg per mL.
Solubility	Reconstitute in 1 mL H2O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

Product Number	P-2408
CAS #	179324-69-7
Chemical Name	MG-341; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Chemical Formula	C₁₉H₂₅BN₄O₄
Appearance	White to off-white solid
Molecular Weight	384.24
Purity	≥99% by HPLC
Solubility	DMSO (200mg/ml) or EtOH (200 mg/ml)
Storage Temp	-20°C

Product Number	S-1142
Chemical Name	2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamidellSir two inhibitor naphthol
Chemical Formula	C₂₆H₂₂N₂O₂
Appearance	Off-White Solid
Molecular Weight	M.W. 394.5
Purity	Purity: ≥95%
Solubility	Soluble in DMSO.

Product Number	S-1082
Alternative Name	pro-SUMO-1/Sentrin-1
Appearance	Lyophilized Powder
Purity	Purity: >95%
Storage Temp	-20°C

Product Number	S-1084
Appearance	Lyophilized Powder
Purity	Purity: >95%
Storage Temp	-20°C

Product Number	T-1180
CAS #	51805-45-9
Chemical Name	tris(2-Carboxyethyl)phosphine.hydrochloride
Chemical Formula	C₉H₁₅O₆P.HCl
Appearance	White Crystalline Solid
Molecular Weight	286.65
Purity	>98%, NMT by elemental analysis
Solubility	Soluble in Water, 50mg/ml.
Storage Temp	+4°C