You have no items in your shopping cart.
You're currently on:
Product Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondra. Selectively blocks oxidative stress-induced necrotic cell death. (0.1μM Necrosis inhibitor 2 prevented ˜50% cell death in H9C2 cells exposed to 400 μM t-BuOOH for 2 hours LDH assay used).
Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).
Does not protect against staurosporine or etoposide induced apoptosis. Protects cells against cold shock, hypoxia abd oxidative stress in vitro.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
H.J. Kim et al. Arch. Pharm. Res. 33. 1813 (2010).
Additional Information
| Product Number | N-1221 |
| Chemical Name | [[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine |
| Chemical Formula | C25H32N4O4S2 |
| Alternative Name | necrox-2 |
| Appearance | Gray Powder |
| Molecular Weight | 516.67 |
| Purity | ≥96% |
| Solubility | Soluble in DMSO (>10mg/ml) |
| Storage Temp | +4°C |
Notice
-
STILL COMPARING & NOT READY TO BUY? CLICK HERE FOR 10 % OFF YOUR NEXT PURCHASE.
-
Require bulk price at a PREFERRED DISCOUNT$$$? CLICK HERE.
-
Follow our latest scientific offerings WITH OUR DAILY BLOG. CLICK HERE.
All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
Double click on above image to view full picture
