HEDGEHOG SIGNALING

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HEDGEHOG SIGNALING

The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes.

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Product Number	G-1247
CAS #	CAS [667463-62-9]
Chemical Name	(2′Z,3′E)-6-Bromoindirubin-3′-oxime
Chemical Formula	C₁₆H₁₀BrN₃O₂
Alternative Name	6BIO , GSK-3 Inhibitor \| CAS [667463-62-9] \| A.G. Scientific
Appearance	Dark Red to Purple solid.
Molecular Weight	M.W.356.2
Preparation	Packaged under inert gas.
Purity	Purity:≥98%
Solubility	DMSO
Storage Temp	-20º C

COA Documentation: G-1247, B1968 6BIO , GSK-3 Inhibitor Product Number: G-1247
Price	Price	Qty	Add to Cart
1x1 mg	$50.00

Product Number	C-2273
CAS #	N/A
Chemical Name	(Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Chemical Formula	C₁₆H₁₇NO₅S₂
Appearance	Yellow solid
Molecular Weight	367.44
Purity	≥98% by HPLC
Solubility	DMSO
Storage Temp	-20°C

CRT Inhibitor, iCRT5 Product Number: C-2273
Price	Price	Qty	Add to Cart
1x5 mg	$85.00
1x25 mg	$355.00

Product Number	C-1405
CAS #	CAS [4449-51-8]
Chemical Formula	C₂₇H₄₁NO₂
Alternative Name	11-Deoxyjervine
Appearance	White Solid
Molecular Weight	M.W. 411.6
Purity	Purity: >98%
RTECS	RTECS: GY0750000
Solubility	Soluble in DMSO, DMF, Ethanol.
Storage Temp	-20°C

COA Documentation: C-1405, B1821 Cyclopamine Product Number: C-1405
Price	Price	Qty	Add to Cart
1x5 mg	$89.00
1x25 mg	$195.00

Product Number	C-2280
CAS #	208255-80-5
Chemical Name	N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Chemical Formula	C₂₃H₂₆F₂N₂O₄
Appearance	White to off-white solid
Molecular Weight	432.46
Purity	≥98% by TLC
Solubility	DMSO (~20 mg/ml)
Storage Temp	-20°C

DAPT Product Number: C-2280
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1x5 mg	$165.00

Product Number	D-2291
CAS #	See under the individual product
Chemical Name	Hedgehog (Hh) Signaling Pathway Inhibitors Set
Chemical Formula	See under the individual product
Appearance	Lyophilized solids
Molecular Weight	See under the individual product
Purity	See under the individual product
Solubility	See under the individual product
Storage Temp	-20°C

DiscoveryPak™ Hedgehog (Hh) Signaling Pathway Inhibitors Set Product Number: D-2291
Price	Price	Qty	Add to Cart
1x6 inhibitors	$475.00

Product Number	G-2333
CAS #	64048-12-0
Chemical Name	2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Chemical Formula	C₂₄H₁₆N₄S
Appearance	Yellow solid
Molecular Weight	392.48
Purity	≥98% by HPLC
Solubility	DMSO (25 mM) or Ethanol (25 mM)
Storage Temp	-20°C

GANT58 Product Number: G-2333
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1x5 mg	$88.00
1x25 mg	$350.00

Product Number	G-1233
CAS #	CAS[500579-04-4]
Chemical Name	2,2’-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl]-benzenamine
Chemical Formula	C₂₇H₃₅N₅
Alternative Name	NSC 136476
Appearance	White to off-white waxy solid
Molecular Weight	M.W.429.6
Purity	Purity:≥95%
Solubility	Soluble in DMSO (5mg/ml).
Storage Temp	-20°C

GANT61 Product Number: G-1233
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1x1 mg	$190.00

Product Number	G-2334
CAS #	879085-55-9
Chemical Name	2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide; HhAntag691
Chemical Formula	C₁₉H₁₄Cl₂N₂O₃S
Appearance	White to off-white solid
Molecular Weight	421.3
Purity	≥98% by HPLC
Solubility	DMSO (200 mg/ml) or EtOH (10 mg/ml with warming)
Storage Temp	-20°C

GDC-0449, Vismodegib Product Number: G-2334
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1x5 mg	$125.00
1x25 mg	$495.00

Product Number	H-2354
CAS #	330796-24-2
Chemical Name	N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl-urea
Chemical Formula	C₂₃H₁₅ClF₄N₄O₂
Appearance	White to off-white solid
Molecular Weight	490.84
Purity	≥97% by HPLC
Solubility	DMSO
Storage Temp	+4°C

Hh Signaling Pathway Antagonist Product Number: H-2354
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1x1 mg	$105.00

Product Number	J-1098
CAS #	CAS [469-59-0]
Chemical Name	(3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one
Chemical Formula	C₂₇H₃₉NO₃
Alternative Name	11-Ketocyclopamine
Appearance	Off White Solid
Melting Point	MP: 243.5-244.5°C
Merck Index	Merck Index: 13.5283
Molecular Weight	M.W. 425.61
Purity	Purity: >98%
RTECS	RTECS: WG9700000
Solubility	Soluble in DMSO (5mg/ml).
Storage Temp	-20°C

Jervine Product Number: J-1098
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1x1 mg	$98.00
1x5 mg	$360.00

Product Number	J-2367
CAS #	315703-52-7
Chemical Name	N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine
Chemical Formula	C₁₉H₁₈N₄OS
Appearance	Beige solid
Molecular Weight	350.44
Purity	≥98% by HPLC
Solubility	DMSO (100 mM) and Ethanol (25 mM)
Storage Temp	-20°C

JK 184 Product Number: J-2367
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1x1 mg	$98.00

Product Number	P-1633
Chemical Name	2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Chemical Formula	C₃₁H₃₂N₆O₂
Alternative Name	Shh Signaling Agonist
Appearance	Beige solid. Packaged under inert gas.
Molecular Weight	M.W.520.6
Purity	Purity:≥98% by HPLC
Solubility	DMSO (200 mg/ml)
Storage Temp	+4ºC

Purmorphamine Product Number: P-1633
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1x1 mg	$40.00
1x5 mg	$145.00

Product Number	R-2028
Chemical Name	N-[(Chlorophenyl)methyl]-2-[2R,6S,8E)-5, 12-Dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Chemical Formula	C₂₅H₂₇ClN₂O₄
Alternative Name	Robotnikinin \| Sonic Hedge Hog (Shh) inhibitor \| Embryogenesis inhibitor
Appearance	White Solid
Molecular Weight	454.95
Purity	≥97%
Solubility	Soluble in DMSO.
Storage Temp	-20°C

Robotnikinin \| Shh inhibitor Product Number: R-2028
Price	Price	Qty	Add to Cart
1x1 mg	$275.00
5x1 mg	$1,150.00

Product Number	S-2162
CAS #	304909-07-7
Chemical Name	N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Chemical Formula	C₂₃H₂₇N₅
Appearance	Pale yellow solid
Molecular Weight	373.49
Purity	≥98% by HPLC
Solubility	DMSO (~50 mM) or EtOH (~25 mM)
Storage Temp	Store at -20°C. Protect from air and light.

SANT-1 Product Number: S-2162
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1x1 mg	$68.00
1x5 mg	$225.00

Product Number	S-2424
CAS #	329196-48-7
Chemical Name	N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Chemical Formula	C₂₆H₂₆ClN₃O₄
Appearance	White to off-white solid
Molecular Weight	479.96
Purity	≥95% by NMR
Solubility	DMSO (100 mM) or EtOH (100 mM)
Storage Temp	-20°C

COA Documentation: T-2424, C1261 SANT-2 Product Number: S-2424
Price	Price	Qty	Add to Cart
1x1 mg	$55.00
1x5 mg	$165.00

Product Number	S-2160
CAS #	364590-63-6
Chemical Formula	C₂₈H₂₈CIN₃OS
Appearance	White to off-white solid
Molecular Weight	490.1
Purity	≥95% (HR-MS, ¹H-NMR, ¹³C-NMR)
Solubility	Soluble in water (5mg/ml) or DMSO (10mg/ml)
Storage Temp	-20°C; Stable for at least 6 months when stored at -20°C.

Smoothened agonist, a.k.a. SAG, a.k.a. Smo agonist Product Number: S-2160
Price	Price	Qty	Add to Cart
1x500 ug	$128.00
1x1 mg	$207.00

Product Number	T-2465
CAS #	6192-62-7
Chemical Name	3β-Hydroxy-5α-tomatidane hydrochloride, 5α-Tomatidan-3β-ol hydrochloride
Chemical Formula	C₂₇H₄₅NO₂ .HCl
Appearance	Off-white solid
Molecular Weight	452.11
Purity	≥90%
Solubility	DMSO (2 mg/ml) or EtOH (2.5 mg/ml)
Storage Temp	-20°C

Tomatidine hydrochloride Product Number: T-2465
Price	Price	Qty	Add to Cart
1x25 mg	$75.00

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HEDGEHOG SIGNALING

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