MAP KINASE PATHWAY

You're currently on:

Home
>
Signaling Pathways
>
MAP KINASE PATHWAY

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.

Click here to View the MAPK Signaling Pathway

Sort by

Product Number	E-2002
CAS #	CAS [989-51-5]
Chemical Name	(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
Chemical Formula	C₂₂H₁₈O₁₁
Alternative Name	EGCG
Appearance	Cream Colored Powder
Merck Index	Merck Index: 13.3557.2001
Molecular Weight	M.W. 458.4
Purity	Purity: ≥98%
Solubility	Soluble in Water.
Storage Temp	+4°C

COA Documentation: E-2002, A9661B (-)-Epigallocatechin gallate Product Number: E-2002
Price	Price	Qty	Add to Cart
1x50 mg	$60.00

Product Number	B-1265
CAS #	CAS[67416-61-9]
Chemical Formula	C₃₂H₄₈O₅
Appearance	White to off-white solid.
Molecular Weight	M.W. 512.7
Purity	Purity: 99% by HPLC, NMR
Solubility	Soluble in acetone, dichloromethane, diethyl ether or DMSO.
Storage Temp	-20°C.

3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata Product Number: B-1265
Price	Price	Qty	Add to Cart
1x5 mg	$145.00

Product Number	A-1208
CAS #	CAS [118409-62-4]
Chemical Name	(3-Hydroxy-4-nitrobenzylidene)malononitrilellα-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
Chemical Formula	C₁₀H₅N₃O₃
Alternative Name	Tyrphostin AG 126, Tyrphostin A10
Appearance	Yellow Solid
Molecular Weight	M.W. 215.2
Purity	Purity: ≥98%
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol.
Storage Temp	-20°C

AG 126 Product Number: A-1208
Price	Price	Qty	Add to Cart
1x5 mg	$75.00

Product Number	A-1108
CAS #	CAS [520-36-5]
Chemical Name	4',5,7-Trihydroxyflavone
Chemical Formula	C₁₅H₁₀O₅
Appearance	Yellow to Brown Solid
Melting Point	MP: 345-350°C
Molecular Weight	M.W. 270.2
Purity	Purity: >97%
Solubility	Soluble in DMSO, Potassium Hydroxyde (diluted); slightly soluble in (hot) 100% Ethanol. Insoluble in Water.
Storage Temp	Room Temperature

COA Documentation: A-1108, B1876 A-1108, C1149 A-1108, C1156 Apigenin Product Number: A-1108
Price	Price	Qty	Add to Cart
1x20 mg	$76.00
1x100 mg	$295.00

Product Number	A-2191
CAS #	4431-00-9
Chemical Name	ATA
Chemical Formula	C₂₂H₁₄O₉
Appearance	Red-brown solid
Molecular Weight	422.4
Purity	>85%
Solubility	1 M NH₄OH (10 mg/ml)
Storage Temp	-20°C

Aurintricarboxylic acid Product Number: A-2191
Price	Price	Qty	Add to Cart
1x1 g	$75.00

Product Number	B-2206
CAS #	N/A
Chemical Name	Biotinyl-Ala-Ser-Thr-DL-Asp-Fluoromethylketone; Biotinyl-ASTD-Fluoromethylketone
Chemical Formula	C₂₅H₃₉FN₆O₁₀S
Appearance	Yellow solid
Molecular Weight	634.68
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	-20°C

Biotinyl-ASTD-FMK Product Number: B-2206
Price	Price	Qty	Add to Cart
1x500 g	$265.00
1x1 mg	$485.00

Product Number	C-1702
CAS #	252917-06-9
Chemical Name	6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021
Chemical Formula	C₂₂H₁₈CI₂N₈
Appearance	Off-white solid
Melting Point	≥95% by HPLC
Molecular Weight	465.34
Solubility	DMSO (100 mM)
Storage Temp	Store at -20°C. Protect from air and light

COA Documentation: C-1702, C1220 A-1702, C1213 CHIR99021 Product Number: C-1702
Price	Price	Qty	Add to Cart
1x5 mg	$195.00
1x25 mg	$695.00

Product Number	C-2279
CAS #	301836-43-1
Chemical Name	4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl) -1H-imidazol-2-yl]benzamide
Chemical Formula	C₂₃H₁₈N₄O₃
Appearance	Off-white solid
Molecular Weight	398.41
Purity	≥98% by HPLC
Solubility	DMSO (100 mM)
Storage Temp	-20°C

D4476 Product Number: C-2279
Price	Price	Qty	Add to Cart
1x1 mg	$75.00
1x5 mg	$295.00

Product Number	D-2294
CAS #	285983-48-4
Chemical Name	1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Chemical Formula	C₃₁H₃₇N₅O₃
Appearance	White to off-white solid
Molecular Weight	527.66
Purity	≥98% by HPLC
Solubility	DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
Storage Temp	-20°C

Doramapimod Product Number: D-2294
Price	Price	Qty	Add to Cart
1x5 mg	$75.00
1x25 mg	$285.00

Product Number	E-2303
CAS #	N/A
Chemical Name	Z-ASTD-FMK, EMAP-II Inhibitor(fluoromethylketone)
Chemical Formula	C₂₄H₃₃FN₄O₁₀
Appearance	Liquid
Molecular Weight	556.54
Purity	>99% by HPLC
Solubility	N/A
Storage Temp	-20°C

EMAP-II Inhibitor Z-ASTD-FMK Product Number: E-2303
Price	Price	Qty	Add to Cart
1x20 l (10 mM)	$195.00

Product Number	G-2339
CAS #	871700-17-3
Chemical Name	N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Chemical Formula	C₂₆H₂₃FIN₅O₄
Appearance	Off-white solid
Molecular Weight	615.39
Purity	≥98% by HPLC
Solubility	DMSO (~ 10 mg/ml)
Storage Temp	-20°C

GSK-1120212 Product Number: G-2339
Price	Price	Qty	Add to Cart
1x1 mg	$75.00
1x5 mg	$295.00

Product Number	H-1042
CAS #	CAS [548-04-9]
Chemical Name	1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione.
Chemical Formula	C₃₀H₁₆O₈
Appearance	Blue-Black Powder
Merck Index	Merck Index: 13.4889.2001
Molecular Weight	M.W. 504.45
Purity	Purity: >98%
Solubility	Soluble in DMSO.
Storage Temp	+4°C

COA Documentation: H-1042, A9225 Hypericin, Hypericum perforatum Product Number: H-1042
Price	Price	Qty	Add to Cart
0x	$0.00
1x1 mg	$73.00
1x5 mg	$269.00

Product Number	L-1043
CAS #	CAS [75330-75-5]
Chemical Name	6-a-Methylcompactin
Chemical Formula	C₂₄H₃₆O₅
Alternative Name	Mevinolin, MK-803
Appearance	White Solid
Merck Index	Merck Index: 13.5608.2001
Molecular Weight	M.W. 404.55
Purity	Purity: >95%
Solubility	Soluble in DMSO and Ethanol.
Storage Temp	+4°C

COA Documentation: L-1043, C1088 L-1043, C1088, r01 Lovastatin Product Number: L-1043
Price	Price	Qty	Add to Cart
1x25 mg	$55.00
1x50 mg	$85.00

Product Number	L-1023
CAS #	CAS [154447-36-6]
Chemical Name	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Chemical Formula	C₁₉H₁₇NO₃
Appearance	White to Off-White Solid.
Molecular Weight	M.W. 307.4
Purity	Purity: >98%
Solubility	Soluble in DMSO(25 mg/ml) and Methanol.
Storage Temp	-20°C

COA Documentation: L-1023, B1934A L-1023, B1934 L-1023, C1309 L-1023, C1333 LY-294002 Product Number: L-1023
Price	Price	Qty	Add to Cart
1x5 mg	$95.00
1x25 mg	$375.00

Product Number	C-1563
Chemical Name	SPECIES CROSS-REACTIVITY: Human, primate, rat. No cross-reactivity with mouse. APPLICATIONS/DILUTIONS: IP (1ug/sample), Western blot (2.5 ug/ml).
Appearance	100 ug purified IgG2a with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	SOURCE: Mice were immunized with recombinant human cdc6 protein and fusing the splenocytes with NS1/Ag4-1 mouse myeloma cells.
Storage Temp	-20º C

Mouse Monoclonal Antibody-cdc6 (Clone 6-36) Product Number: C-1563
Price	Price	Qty	Add to Cart
1x100 ug	$250.00

Product Number	C-1541
Chemical Name	SPECIES CROSS-REACTIVITY: Human, primate, Not mouse or rat. APPLICATIONS/DILUTIONS: Western blot (2.5 ug/ml).
Appearance	100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	SOURCE: Mice were immunized with recombinant human cdc6 protein and fusing the splenocytes with NS1/Ag4-1 mouse myeloma cells.
Storage Temp	-20º C

Mouse Monoclonal Antibody-cdc6 (Clone 6-37) Product Number: C-1541
Price	Price	Qty	Add to Cart
1x100 ug	$250.00

Product Number	P-1645
Appearance	Formulation: 8 mg/ml in 25 mM Tris-HCl, pH8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Molecular Weight	Properties: Mass – calculated 33,646 Da, measured – 33,728 (1P), 33,808 (2P), 33,889 (3P), 33,968 (4P). pI = 5.3
Purity	Method of Purification: Ni-NTA; Protease cleavage of His-tag followed by reverse Ni-NTA; S200 size-exclusion.
Storage Temp	-80°C

PAK1, kinase domain Product Number: P-1645
Price	Price	Qty	Add to Cart
1x10 ug	$355.00

Product Number	P-1643
Appearance	Formulation: 4 mg/ml in 25 mM Tris-HCl, pH8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Purity	Method of Purification:Ni-NTA; Protease cleavage of His-tag followed by reverse Ni-NTA; S200 size-exclusion.
Storage Temp	-80°C

PAK2, kinase domain Product Number: P-1643
Price	Price	Qty	Add to Cart
1x10 ug	$355.00

Product Number	P-1233
CAS #	CAS [20554-84-1]
Chemical Formula	C₁₅H₂₀O₃
Appearance	White Solid
Molecular Weight	M.W. 248.3
Purity	Purity: >98%
Solubility	Soluble in DMSO and Ethanol.
Storage Temp	-20°C

COA Documentation: P-1233, A9355 Parthenolide Product Number: P-1233
Price	Price	Qty	Add to Cart
1x50 mg	$69.00
1x250 mg	$195.00

Product Number	P-2383
CAS #	See under the individual product
Chemical Name	MAP Kinase Signaling Inhibitor Panel, PathwayReady™
Chemical Formula	See under the individual product
Appearance	Lyophilized solids
Molecular Weight	See under the individual product
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	-20°C

PathwayReady™ MAP Kinase Signaling Inhibitor Panel Product Number: P-2383
Price	Price	Qty	Add to Cart
1x7 inhibitors	$545.00

Product Number	P-1713
CAS #	212631-67-9
Chemical Name	5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-benzamide
Chemical Formula	C₁₇H₁₃BrClF₂IN₂O₂
Appearance	A crystalline solid
Molecular Weight	557.6
Purity	≥98%
Storage Temp	-20°C

COA Documentation: P-1713, C1289 PD 184161 Product Number: P-1713
Price	Price	Qty	Add to Cart
1x5 mg	$95.00
1x10 mg	$168.00
1x25 mg	$368.00

Product Number	E-2314
CAS #	167869-21-8
Chemical Name	2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Chemical Formula	C₁₆H₁₃NO₃
Appearance	Liquid
Molecular Weight	267.28
Purity	≥98% by HPLC
Solubility	N/A
Storage Temp	-20°C

PD 98059 EZSolution™ Product Number: E-2314
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	P-1019
CAS #	CAS [167869-21-8]
Chemical Name	2'-Amino-3'methoxyflavone
Chemical Formula	C₁₆H₁₃NO₃
Alternative Name	MEK Inhibitor
Appearance	Pale to Yellow Solid
Molecular Weight	M.W. 267.3
Preparation	Solutions may be stored at -20°C for up to 3 months.
Purity	Purity: >95%
Solubility	Soluble in DMSO (~6mg/ml), Methanol, DMF, or 100% Ethanol
Storage Temp	-20°C

COA Documentation: P-1019, B1502A P-1019, B1502B P-1019, C1276 PD-98059 Product Number: P-1019
Price	Price	Qty	Add to Cart
1x5 mg	$84.00

Product Number	B-1253
Alternative Name	Anti-β-Secretase 1, Anti-Aspartyl Protease 2
Appearance	0.2 ml (100 μg) of purified total IgG in PBS with 0.02% sodium azide.
Storage Temp	-20°C

Polyclonal Antibody to-BACE1 Product Number: B-1253
Price	Price	Qty	Add to Cart
1x0.2 ml	$270.00

Polyclonal Antibody to-BACE2 Product Number: B-1255
Price	Price	Qty	Add to Cart
1x0.2 ml	$270.00

Proteinase K 20mg/ml Solution Product Number: P-1266
Price	Price	Qty	Add to Cart
1x2 ML	$61.00
1x10 ML	$225.00

COA Documentation: S-1080, A7040, r01 S-1080, B1000A SB-202190 Product Number: S-1080
Price	Price	Qty	Add to Cart
1x1 mg	$96.00

SB-203580 in Solution Product Number: S-1015
Price	Price	Qty	Add to Cart
1x1 ml	$199.00

COA Documentation: S-1014, B1534A S-1014, C1107 SB-203580 \| specific inhibitor of p38 MAP Kinase Product Number: S-1014
Price	Price	Qty	Add to Cart
1x1 mg	$82.00
1x5 mg	$320.00

SH-5 Product Number: S-2024
Price	Price	Qty	Add to Cart
1x500 μg	$140.00
1x1mg	$240.00

SH-6 Product Number: S-2026
Price	Price	Qty	Add to Cart
1x500 μg	$140.00
1x1 mg	$240.00

VX-702 Product Number: V-2481
Price	Price	Qty	Add to Cart
1x1 mg	$295.00
1x5 mg	$895.00

MSDS Documentation: W-1022, Wortmannin, MSDS COA Documentation: W-1022, B1828 W-1022, B1901 W-1022, D1029 Wortmannin, Penicillium wortmanni Product Number: W-1022
Price	Price	Qty	Add to Cart
1x1 mg	$50.00
1x5 mg	$150.00
1x25 mg	$585.00

Sort by

Toll free 1-858-452-9925

Category Navigation:

You're currently on:

MAP KINASE PATHWAY

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

COA Documentation:

MSDS Documentation:

COA Documentation:

Product Number	B-1255
Alternative Name	Anti-β-Secretase-2, Anti-Aspartyl Protease 1
Appearance	0.2 ml (100 μg) of peptide purified IgG in PBS with 0.02% sodium azide
Storage Temp	-20°C

Product Number	P-1266
Alternative Name	Endopeptidase K
Appearance	Liquid
Purity	Activity: >30 units/mg solid
RTECS	Free of detectable DNase and RNase
Storage Temp	-20°C

Product Number	S-1080
CAS #	CAS [152121-30-7]
Chemical Name	4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Chemical Formula	C₂₀H₁₄FN₃O
Alternative Name	FHPI
Appearance	Light Yellow to Brown Solid
Molecular Weight	M.W. 331.3
Purity	Purity: >98%
Solubility	Soluble in Methanol, DMSO or Acetone; slightly Soluble in Ethyl Acetate.
Storage Temp	-20°C

Product Number	S-1015
Chemical Name	4-(4-Fluorophenyl)-2-(4-methylsulfinyl phenyl)-5-(4-pyridyl) 1H-imidazole
Chemical Formula	C₂₁H₁₆N₃FOS
Appearance	1 mg/ml Clear Solution in DMSO
Molecular Weight	M.W. 377.4
Purity	Purity: >98%
Storage Temp	-20°C

Product Number	S-1014
CAS #	CAS[152121-47-6]
Chemical Name	4-(4-Fluorophenyl)-2-(4-methylsulfinyl phenyl)-5-(4-pyridyl) 1H-imidazole
Chemical Formula	C₂₁H₁₆N₃FOS
Appearance	White to Off-White Solid
Molecular Weight	M.W. 377.4
Purity	Purity: >98%
Solubility	Soluble in DMSO (50mg/ml) or methanol.
Storage Temp	-20°C

Product Number	S-2024
Chemical Name	D-3-Deoxy-2-O-methyl-myo inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Chemical Formula	C₂₉H₅₉O₁₀P
Appearance	White to Off-White Solid.
Molecular Weight	M.W. 598.7
Purity	Purity: >98%
Solubility	Soluble in DMSO, Methanol or Water.
Storage Temp	+4°C

Product Number	S-2026
Chemical Name	D-2,3-Dideoxy-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate]
Chemical Formula	C₂₈H₅₇O₉P
Appearance	White to Off-White Solid.
Molecular Weight	M.W. 568.7
Purity	Purity: >98%
Solubility	Soluble in DMSO, Methanol or Water.
Storage Temp	+4°C

Product Number	V-2481
CAS #	479543-46-9
Chemical Name	2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide
Chemical Formula	C₁₉H₁₂F₄N₄O₂
Appearance	White soild
Molecular Weight	404.32
Purity	≥99% by HPLC
Solubility	DMSO
Storage Temp	-20°C

Product Number	W-1022
CAS #	CAS [19545-26-7]
Chemical Formula	C₂₃H₂₄O₈
Alternative Name	KY12420
Appearance	Off-White to Pale Yellow Solid
Melting Point	MP: 240°C
Merck Index	Merck Index: 13.10110.2001
Molecular Weight	M.W. 428.4
Purity	Purity: >98%
RTECS	RTECS: CB9641000
Solubility	Soluble in Methanol and DMSO.
Storage Temp	-20°C