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PPAR SIGNALING
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to a nuclear hormone receptor superfamily, containing three isoforms (α, β/δ, and γ). PPARs are activated by naturally occurring fatty acids or fatty acid derivatives (e.g. eicosanoids) and play a critical physiological role in the regulation of numerous biological processes, including lipid and glucose metabolism, and overall energy homeostasis.
FREE REVIEW ARTICLES
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PPAR-γ as a Therapeutic Target in Cardiovascular Disease: Evidence and Uncertainty, Janice V. Huang, MD, Clifford R. Greyson, MD, Gregory G. Schwartz MD PhD; VA Medical Center and University of Colorado Denver School of Medicine, Denver, CO USA
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Nuclear Receptors of the Peroxisome Proliferator-Activated Receptor (PPAR) Family in Gestational Diabetes: From Animal Models to Clinical Trials Petra Arck,3,4 Bettina Toth,5 Aurelia Pestka,6 and Udo Jeschke2,6, Center for Internal Medicine,3 Charite´ University Medicine Berlin, Berlin, Germany Department of Medicine,4 McMaster University, Hamilton, Ontario, Canada Department of Gynecological Endocrinology and Infertility Disorders,5 Ruprecht Karl University, Heidelberg, Germany Department of Obstetrics and Gynecology,6 Ludwig Maximilians University Munich, Munich, Germany
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The PPAR-RXR Transcriptional Complex in the Vasculature Energy in the Balance, Author Jorge Plutzky
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The many facets of PPAR: novel insights for the skeleton, Masanobu Kawai,1 Kyle M. Sousa,2 Ormond A. MacDougald,2 and Clifford J. Rosen11Maine Medical Center Research Institute, Scarborough, Maine; and 2Department of Molecular and Integrative Physiology,University of Michigan, Ann Arbor, Michigan, Am J Physiol Endocrinol Metab 299: E3–E9, 2010., First published April 20, 2010; doi:10.1152/ajpendo.00157.2010.
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