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Product Description
A potent SIRT1 inhibitor (IC50 = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
Additional Information
| Product Number | S-2432 |
| CAS # | 49843-98-3 |
| Chemical Name | EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
| Chemical Formula | C13H13ClN2O |
| Appearance | White solid |
| Molecular Weight | 248.71 |
| Purity | ≥97% by HPLC |
| Solubility | DMSO (20 mg/ml) |
| Storage Temp | +4°C |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
