PI3K / AKT SIGNALING

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PI3K / AKT SIGNALING

The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in apoptosis and hence cancer e.g. breast cancer and non-small-cell lung cancer. mTOR signaling pathway. PI3K activation activates AKT which activates mTOR. ('PDK1' in the diagram is Phosphoinositide-dependent kinase-1.)

In many cancers this pathway is overactive reducing apoptosis and allowing proliferation. Thus some experimental cancer drugs aim to inhibit the signalling sequence at some point. The PI3K pathway may be overactive because PTEN is faulty or deficient.

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Product Number	A-1094
CAS #	CAS [14375-45-2]
Chemical Name	2-cis-4-trans-Abscisic acid; (±)-Abscisic acid; ABA; (2-cis,4-trans)-5-(1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl)-3-methyl-2,4-pentadienoic acid
Chemical Formula	C₁₅H₂₀O₄
Appearance	White Solid
Melting Point	MP: 183-186°C
Molecular Weight	M.W. 264.3
Purity	Purity: >99%
Solubility	Soluble in Ethanol.
Storage Temp	-20°C

COA Documentation: A-1094, A9076 A-1094, B1289 (±)-cis,trans-(±)-cis,trans-Abscisic Acid Product Number: A-1094
Price	Price	Qty	Add to Cart
0x inquire	$0.00

Product Number	D-1113
Chemical Name	D-3-Deoxy-myo-inositol 1-[(R)-2,3-bis(hexadecanoyloxy)propyl hydrogenphosphate
Chemical Formula	C₄₁H₇₉O₁₂P
Alternative Name	DPI
Appearance	Off-White Solid
Molecular Weight	M.W. 795.0
Purity	Purity: >98%
Solubility	Soluble in Ethanol or DMSO.
Storage Temp	+4°C

1-D-3-Deoxy-phophatidylinositol Product Number: D-1113
Price	Price	Qty	Add to Cart
1x100 μg	$22.00
1x1 mg	$105.00

Product Number	D-1109
CAS #	CAS [129365-68-0]
Chemical Name	3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphat.hexasodium salt
Chemical Formula	C₆H₈FO₁₄P₃.₆Na
Appearance	White to off-white solid
Molecular Weight	M.W. 416.0 . 137.9
Purity	Purity:>99%
Solubility	Soluble in Water.
Storage Temp	-20°C

3-F-Deoxy-Ins(1,4,5)P3. 6Na Product Number: D-1109
Price	Price	Qty	Add to Cart
1x100 ug	$28.00

Product Number	A-1762
Chemical Name	1L-6-Hydroxymethyl-chiro-inositol2-[(R)-2-O-methyl-3-O-octadecylcarbonate]
Chemical Formula	C₃₀H₅₈O₁₀
Appearance	White to off-white powder
Molecular Weight	578.8
Purity	≥98%
Solubility	Soluble in DMSO
Storage Temp	-20°C

COA Documentation: A-1762, C1258 Akt Inhibitor Product Number: A-1762
Price	Price	Qty	Add to Cart
1x1 mg	$140.00

Product Number	B-2199
CAS #	915019-65-7
Chemical Name	NVP-BEZ235
Chemical Formula	C₃₀H₂₃N₅O
Appearance	Off-white to pale yellow solid
Molecular Weight	469.55
Purity	≥99% by HPLC
Solubility	DMSO (10 mM)
Storage Temp	-20°C

BEZ235 (NVP-BEZ235) Product Number: B-2199
Price	Price	Qty	Add to Cart
1x5 mg	$125.00
1x25 mg	$295.00

Product Number	D-2292
CAS #	See under the individual product
Chemical Name	PI 3-Kinase Inhibitor Set, DiscoveryPak™
Chemical Formula	See under the individual product
Appearance	Lyophilized solids
Molecular Weight	See under the individual product
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	-20°C

DiscoveryPak™ PI 3-Kinase Inhibitor Set Product Number: D-2292
Price	Price	Qty	Add to Cart
1x5 inhibitors	$435.00

Product Number	F-1164
CAS #	480-49-9
Chemical Formula	C₃₅H₅₈O₁₁
Appearance	A crystalline solid
Molecular Weight	654.8
Purity	≥85%

Filipin III Product Number: F-1164
Price	Price	Qty	Add to Cart
1x1 mg	$106.00
1x5 mg	$448.00
1x10 mg	$784.00

Product Number	G-2335
CAS #	957054-30-7
Chemical Name	2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Chemical Formula	C₂₃H₂₇N₇O₃S₂
Appearance	Off-white solid
Molecular Weight	513.64
Purity	≥99% by HPLC
Solubility	DMSO
Storage Temp	-20°C

GDC-0941 Product Number: G-2335
Price	Price	Qty	Add to Cart
1x1 mg	$295.00
1x5 mg	$895.00

Product Number	I-1042
CAS #	CAS [573-35-3 ]
Chemical Name	D-myo-Inositol 1-phosphate. Dipotassium Salt
Chemical Formula	C₆H₁₁O₉P.2K
Appearance	White to Off-white Solid
Molecular Weight	M.W. 336.3
Purity	Purity: >98%
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: I-1042, A9669 Ins(1)P. 2K Product Number: I-1042
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1x1 mg	$63.00
1x5 mg	$170.00

Product Number	I-1066
Chemical Name	D-myo-Inositol 3,4,5.trisphosphate.tripotassium salt, Synthetic
Chemical Formula	C₆H₁₂O₁₅P₃. 3K
Appearance	Lyophilized White powder.
Molecular Weight	M.W. 417.1 . 117.3
Purity	Purity: >98% (HPLC)
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: I-1066, B1314 Ins(3,4,5)P3.3K Product Number: I-1066
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1x100 ug	$76.00

Product Number	P-1111
Chemical Name	D-myo-Inositol 3,4,5,6-tetraphosphate.potassium salt, Synthetic
Chemical Formula	C₆H₈O₁₈P₄K₈
Appearance	Lyophilized White powder
Molecular Weight	F.W. 804
Purity	Purity: >98%
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: P-1111, B1377 Ins(3,4,5,6)P4 Product Number: P-1111
Price	Price	Qty	Add to Cart
1x100 μg	$173.25
1x500 μg	$441.00

Product Number	I-1038
Chemical Name	L-myo-Inositol 1,4,5-trisphosphate.6K, Synthetic
Appearance	Crystalline Solid
Purity	Purity: >99%
Storage Temp	+4°C

L-myoIns(1,4,5)P3.6K Product Number: I-1038
Price	Price	Qty	Add to Cart
1x1 mg	$110.25

Product Number	N-1053
CAS #	CAS [1405-10-3]
Chemical Formula	C₂₃H₄₆N₆O₁₃.₃H₂SO₄
Appearance	White to off-white solid
Merck Index	Merck Index: 13.6482.2001
Molecular Weight	M.W. 908.9
Purity	Activity: >600IU/mg
RTECS	RTECS: QP4375000
Solubility	Soluble in Water.
Storage Temp	+4°C

COA Documentation: N-1053, A8397 Neomycin.Sulfate Product Number: N-1053
Price	Price	Qty	Add to Cart
1x25 g	$17.00
1x100 g	$42.00

Product Number	N-1171
CAS #	CAS[1400-61-9]
Alternative Name	Fungicidin, Mycostatin
Solubility	Soluble in DMSO. Nystatin is only slightly soluble in water and alcohol.
Storage Temp	-20°C

COA Documentation: N-1171, B1037 N-1171, B1037, r02 Nystatin Product Number: N-1171
Price	Price	Qty	Add to Cart
1x5 g	$40.00

Product Number	P-2384
CAS #	See under the individual product
Chemical Name	PI3-K/Akt/mTOR Signaling Inhibitor Panel, PathwayReady™
Chemical Formula	See under the individual product
Appearance	Lyophilized solids
Molecular Weight	See under the individual product
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	-20°C

PathwayReady™ PI3-K/Akt/mTOR Signaling Inhibitor Panel Product Number: P-2384
Price	Price	Qty	Add to Cart
1x11 inhibitors	$935.00

Product Number	P-1143
Chemical Formula	C₅₁H₉₅N₂₃O₉
Alternative Name	PI3K SH3.Trifluoroacetate salt, PI3-kinase SH3 domain binding peptide
Appearance	Lyophilized Solid
Molecular Weight	M.W. 1174.5
Purity	Purity: >98%
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: P-1143, A9026 Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide Product Number: P-1143
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1x1 mg	$88.00

Product Number	P-1555
Chemical Formula	C₂₅H₄₇O₁₃P₁
Alternative Name	L-alpha-D-myo-Phosphatidylinositol 3-O- phospho linked, D(+)-sn-1,2-di-O-octanoylglyceryl
Molecular Weight	M.W.586.0
Purity	Purity:98%
Solubility	Soluble in Aqueous media
Storage Temp	-20°C

COA Documentation: P-1555, D1009 PI diC8 Product Number: P-1555
Price	Price	Qty	Add to Cart
1x500 ug	$215.00
1x1 mg	$405.00

Product Number	P-1557
Chemical Formula	C₄₁H₇₉O₁₃P₁
Alternative Name	L-alpha-D-myo-Phosphatidylinositol 3-O-phospo linked, D(+)-sn-1,2-di-O-hexadecanoylglyceryl
Molecular Weight	M.W.810
Purity	Purity:98
Solubility	Soluble in Organic Solvents including DMSO, Cloroform, Ethanol
Storage Temp	-20°C

PI(3)diC16 Product Number: P-1557
Price	Price	Qty	Add to Cart
1x500 ug	$215.00
1x1 mg	$405.00

Product Number	P-1137
Chemical Name	L-α-D-myo-Phosphatidylinositol 4-monosphosphate, 3-O-phospho linked, D(+)-sn-1,2-di-O-hexadecanoylglyceryl, Free Acid, Synthetic
Chemical Formula	C₄₁H₈₀O₁₆P₂
Alternative Name	PtdIns-4-P(diC16)
Appearance	Lyophilized powder
Molecular Weight	F.W. 890
Purity	Purity: >99%
Solubility	Soluble in ethanol, chloroform, and DMSO.
Storage Temp	-20°C

COA Documentation: P-1137, B1887 PI(4)P, di C16 Product Number: P-1137
Price	Price	Qty	Add to Cart
1x100 μg	$60.00
1x500 μg	$210.00

Product Number	P-1135
Chemical Name	L-α-D-myo-Phosphatidylinositol 4-monosphosphate, 3-O-phospho linked, D(+)-sn-1,2-di-O-octanoylglyceryl, Free Acid, Synthetic
Chemical Formula	C₂₅H₄₈O₁₆P₂
Alternative Name	PtdIns-4-P(diC8)
Appearance	Lyophilized powder
Molecular Weight	F.W. 666
Purity	Purity: >99%
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: P-1135, C1229 PI(4)P, di C8 Product Number: P-1135
Price	Price	Qty	Add to Cart
1x100 μg	$90.00
1x500 μg	$270.00

Product Number	P-1117
Chemical Name	L-α-D-myo-Phosphatidylinositol 4,5-bisphosphate, 3-O-phospho linked, D(+)-sn-1,2-di-O-hexadecanoylglyceryl, Free Acid, Synthetic
Chemical Formula	C₄₁H₈₁O₁₉P₃
Alternative Name	PtdIns-4,5-P2(diC16)
Appearance	Lyophilized powder
Molecular Weight	F.W. 970
Purity	Purity: >99%
Solubility	Soluble in Ethanol, Chloroform and DMSO.
Storage Temp	-20°C

COA Documentation: P-1117, B1982 PI(4,5)P2, di C16 Product Number: P-1117
Price	Price	Qty	Add to Cart
1x100 μg	$60.00
1x500 μg	$210.00

Product Number	P-1115
Chemical Name	L-α-D-myo-Phosphatidylinositol 4,5-bisphosphate, 3-O-phospho linked, D(+)-sn-1,2-di-O-octanoylglyceryl, Free Acid, Synthetic
Chemical Formula	C₂₅H₄₉O₁₉P₃
Alternative Name	PtdIns-4,5-P2(diC8)
Appearance	Lyophilized powder
Molecular Weight	F.W. 746
Purity	Purity: >99%
Solubility	Soluble in Water.
Storage Temp	-20°C

COA Documentation: P-1115, B1196 P-1115, B1983 PI(4,5)P2,di C8 Product Number: P-1115
Price	Price	Qty	Add to Cart
1x100 μg	$60.00
1x500 μg	$210.00

Product Number	P-1141
Chemical Name	L-α-D-myo-Phosphatidylinositol 5-monophosphate, 3-O-phospho linked, D(+)-sn-1,2-di-O-hexadecanoylglyceryl, Free Acid, Synthetic
Chemical Formula	C₄₁H₈₀O₁₆P₂
Alternative Name	PtdIns-5-P(diC16)
Appearance	Lyophilized powder
Molecular Weight	F.W. 890
Purity	Purity: >99%
Solubility	Soluble in ethanol, chloroform, and DMSO.
Storage Temp	-20°C

COA Documentation: P-1141, A9428 PI(5), di C16 Product Number: P-1141
Price	Price	Qty	Add to Cart
1x100 μg	$60.00
1x500 μg	$210.00

Product Number	P-2394
CAS #	371935-74-9
Chemical Name	3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Chemical Formula	C₁₉H₁₆N₄O₃
Appearance	Off-white solid
Molecular Weight	348.36
Purity	≥98% by HPLC
Solubility	DMSO (50 mM)
Storage Temp	-20°C

PI-103 Product Number: P-2394
Price	Price	Qty	Add to Cart
1x1 mg	$90.00
1x5 mg	$325.00

PI3-Kɣ Inhibitor, AS-605240 Product Number: P-2395
Price	Price	Qty	Add to Cart
1x1 mg	$65.00
1x5 mg	$245.00

TGX-221 Product Number: T-2460
Price	Price	Qty	Add to Cart
1x1 mg	$85.00
1x5 mg	$325.00

MSDS Documentation: W-1022, Wortmannin, MSDS COA Documentation: W-1022, B1828 W-1022, B1901 W-1022, D1029 Wortmannin, Penicillium wortmanni Product Number: W-1022
Price	Price	Qty	Add to Cart
1x1 mg	$50.00
1x5 mg	$150.00
1x25 mg	$585.00

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PI3K / AKT SIGNALING

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Product Number	P-2395
CAS #	648450-29-7
Chemical Name	5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Chemical Formula	C₁₂H₇N₃O₂S
Appearance	Pink to reddish solid
Molecular Weight	257.27
Purity	≥98% by HPLC
Solubility	DMSO ( 1 mM)
Storage Temp	-20°C

Product Number	T-2460
CAS #	663619-89-4
Chemical Name	(±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one
Chemical Formula	C₂₁H₂₄N₄O₂
Appearance	White solid
Molecular Weight	364.44
Purity	≥98% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Temp	-20°C

Product Number	W-1022
CAS #	CAS [19545-26-7]
Chemical Formula	C₂₃H₂₄O₈
Alternative Name	KY12420
Appearance	Off-White to Pale Yellow Solid
Melting Point	MP: 240°C
Merck Index	Merck Index: 13.10110.2001
Molecular Weight	M.W. 428.4
Purity	Purity: >98%
RTECS	RTECS: CB9641000
Solubility	Soluble in Methanol and DMSO.
Storage Temp	-20°C