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A potent and selective inhibitor (IC50 = 700 nM) of vascular endothelial growth factor receptor 2 (VEGFR 2) (also known as Flk1). Very weak inhibitor of PDGFR-kinase (IC50 >50 µM), EGFR-kinase (IC50 >100 µM)and HER-2 kinase (IC50>100 µM). SU1498 has been shown to cause accumulation of phosphorylated ERK and inhibits its activity in vivo and in vitro by inhibition of ERK dephosphorylation.
|Chemical Name||Tyrphostin SU 1498; (E)-N-(3″-Phenylpropyl)-α-cyano-3′,5′-diisopropyl-4′-hydroxycinnamamide|
|Purity||≥98% by TLC|
|Solubility||DMSO (~20 mg/ml)|
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