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Vincristine.sulfate blocks mitotic spindle formation, which impedes the cell cycle in G2/M phase. Blocks binding of tubulin to microtubule proteins through depolymerization. Also acts as inducer to apoptosis; initiates Raf-1 activation & phosphorylation of Bcl-2 family proteins; and induction of p53 expression. Used as cancer chemotherapeutic agent. Plant alkaloid.
|CAS #||CAS [2068-78-2]|
|Alternative Name||Leurocristine; VCR.sulfate|
|Appearance||White to Off White Solid|
|Merck Index||Merck Index: 13.10048.2001|
|Molecular Weight||M.W. 923.1|
|Solubility||Soluble in Methanol and Water.|
|Storage Temp||-20°C, Stock solutions <3 months at -20C|
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