![Withaferin A| CAS [ 5119-48-2 ] |potent angiogenesis inhibitor.| Neuroregenerative properties. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, & immunosuppressive](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_4.gif "Withaferin A| CAS [ 5119-48-2 ] |potent angiogenesis inhibitor.| Neuroregenerative properties. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, & immunosuppressive")
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Product Description
Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides.Withaferin A inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo.
Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Our docking results obtained substantiate the hypothesis that Wthaferin A has the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37.
Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability.
Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentin
Withaferin A binds to and down-regulates soluble vimentin and GFAP expression to cause cell cycle G0/G1 arrest.
Finally, Withaferin A displays neuronal regenerative properties.
Bulk sizes & pricing available, inquire for more details.
Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Our docking results obtained substantiate the hypothesis that Wthaferin A has the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37.
Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability.
Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentin
Withaferin A binds to and down-regulates soluble vimentin and GFAP expression to cause cell cycle G0/G1 arrest.
Finally, Withaferin A displays neuronal regenerative properties.
Bulk sizes & pricing available, inquire for more details.
Additional Information
COA Documentation: |
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| Product Number | W-1042 |
| CAS # | CAS[5119-48-2] |
| Chemical Name | [5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide] |
| Chemical Formula | C28H38O6 |
| Alternative Name | Isolated from Whithania somnifera |
| Appearance | White to off-white solid. |
| Merck Index | Merck: 14:10048 |
| Molecular Weight | M.W.470.6 |
| Purity | Purity:≥98% (HPLC) |
| RTECS | KE7288500 |
| Solubility | DMSO (20 mg/ml), methanol (10 mg/ml), 100% ethanol |
| Storage Temp | -20°C |
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![Withaferin A| CAS [ 5119-48-2 ] |potent angiogenesis inhibitor.| Neuroregenerative properties. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, & immunosuppressive](http://www.agscientific.com/media/catalog/product/cache/1/image/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_lg_1.gif "Withaferin A| CAS [ 5119-48-2 ] |potent angiogenesis inhibitor.| Neuroregenerative properties. Inhibits endothelial cells (HUVEC) sprouting in vitro (IC50=12nM) and in vivo. Exhibits antitumor, anti-inflammatory, radiosensitizing, & immunosuppressive")
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