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Withaferin A, WFA

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Withaferin A, WFA

CAS: 5119-48-2 Formula: C28H38O6 MW: 470.6 Appearance: White to off-white Solid Purity: 98% (HPLC)
Hazardous

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W-1042 1 mg
$81.53
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5 mg
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Withaferin A is cell permeable and potent angiogenesis inhibitor from the family of withanolides. Withaferin A inhibits endothelial cells (HUVEC) sproutingin vitro (IC50=12nM) andin vivo. Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Our docking results obtained substantiate the hypothesis that Wthaferin Ahas the potential to inhibit the association of chaperone (Hsp90) to its co-chaperone (Cdc37) by disrupting the stability of attachment of Hsp90 to Cdc37. Conclusively our results strongly suggest that withaferin A is a potent anticancer agent as ascertained by its potent Hsp90-client modulating capability. Gliosis is a biological process that occurs during injury repair in the central nervous system and is characterized by the overexpression of the intermediate filaments (IFs) glial fibrillary acidic protein (GFAP) and vimentinWithaferin Abinds to and down-regulates soluble vimentin and GFAP expression to cause cell cycle G/G arrest.Finally, Withaferin A displays neuronal regenerative properties.

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Synonyms [5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide], WA, WFA
Product # W-1042
CAS # 5119-48-2
Chemical Name [5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide]
Formula C28H38O6
MW 470.6
Appearance White to off-white Solid
Purity 98% (HPLC)
Solubility DMSO (20 mg/ml), methanol (10 mg/ml),100% ethanol
Boiling Point 680.7±55.0 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use An antiangiogenesis compound and poteasome inhibitor.Withaferin A exhibits antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties

Additional Information

Merck Index Merck: 14:10048
MDL Number MFCD10687098
ChemACX X1710961-6
InChI InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
SMILES CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO

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RTECS KE7288500
Handling Protect from LightHARMFUL.Maybe Carcinogenic and Mutagenic.

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Certificate of Analysis 1 W-1042_W-1042,_B1989.pdf

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Withaferin A, WFA

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