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Wortmannin, Penicillium wortmanni

Wortmannin, Penicillium wortmanni
Product Number: W-1022
Price Price Qty Add to Cart
1x1 mg
$50.00
1x5 mg
$150.00
1x25 mg
$550.00

Product Description

A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase (MAPK) and myosin light-chain kinase (MLCK).

Seeking published researchers utilizing our Wortmannin product? Hit the hot link for the full paper.

1.     Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells, Jong-Soo Kim, Tatiana B. Krasieva, et al, Aug 2005; 170: 341 - 347.


 

Additional Information

Product Number W-1022
CAS # CAS [19545-26-7]
Chemical Formula C23H24O8
Alternative Name KY12420
Appearance Off-White to Pale Yellow Solid
Melting Point MP: 240°C
Merck Index Merck Index: 13.10110.2001
Molecular Weight M.W. 428.4
Purity Purity: >98%
RTECS RTECS: CB9641000
Solubility Soluble in Methanol and DMSO.
Storage Temp -20°C

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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.

Wortmannin, Penicillium wortmanni

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  • Wortmannin| CAS [19545-26-7 ]|Anti-tumor agent | Inhibits PI-3 | A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase (MAPK) and myosin light-chain kinase (MLCK).Wortmannin inhibits the grow
  • Src activation to induce conversion of (PI4,5P2) to (P3,4,5IP3) by (PI3K). PIP3 formation is required for phosphorylation (P) of Akt by the kinase PDK-1. Treatment with simvastatin (statins) increases Akt phosphorylation,whereas wortmannin prevents it
  • Wortmannin| CAS [19545-26-7 ]|, The PI metabolic pathway and wortmannin sensitivity. Wortmannin-resistant deletions are labeled green, and wortmannin-hypersensitive deletions are labeled red. Dashed lines represent processes found only in mammalian cells.
 

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