Actin is a family of globular multi-functional proteins that form microfilaments. Microfilaments, also called actin filaments, are filaments in the cytoplasm of eukaryotic cells that form part of the cytoskeleton. Actin participates in many important cellular processes, including muscle contraction, cell motility, cell division and cytokinesis, vesicle and organelle movement, cell signaling, and the establishment … Continue reading CK-666

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SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases. It is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such … Continue reading SMER28- An mTOR-independent small molecule enhancer of autophagy

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  Dithiothreitol or DTT is also known as Cleland’s Reagent. It contains two thiol groups and is commonly used to reduce disulfide bond in proteins. It can protect many thiol-containing biomolecules such as coenzyme A (Co-A), GSH (glutathione) from forming disulfide bonds. Not only does DTT scavenge the hydroxyl radical that attacks DNA and proteins, … Continue reading Dithiothreitol aka Cleland’s Reagent

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