17-AAG

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17-AAG

A-1256
  • CAS: 75747-14-7
  • Formula: C31H43N3O8
  • MW: 585.7
  • Appearance: Purple Powder
  • Purity: >99%

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17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as client proteins. These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others.17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.

Additional Information

SynonymsTanespimycin
Product #A-1256
CAS #75747-14-7
Chemical Name17-(Allylamino)-17-demethoxygeldanamycin
FormulaC31H43N3O8
MW585.7
AppearancePurple Powder
Purity>99%
SolubilityDMSO, Methanol: Clear purple solution at 10 mg/ml
Melting Point207-208°C
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseA potent Hsp90 inhibitor for tumor cells

Additional Information

MDL NumberMFCD04973892
ChemACXX1367336-8
InChIInChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10-,20-15-/t17-,19+,24+,25+,27-,29+/m1/s1
SMILESC[C@H]1C[C@@H]([C@@H]([C@H](/C=C([C@@H]([C@H](/C=CC=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)/C)C)O)OC

Additional Information

GHS Pictograms
HandlingStore in tightly Sealed Vial Protect from Light

Additional Information

msds 1A-1256, 17-AAG, SDS, diamond format.pdf
Certificate of Analysis 1A-1256, E1348H.pdf
Certificate of Analysis 2A-1256, E1348G.pdf
Certificate of Analysis 3A-1256, E1348F.pdf
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