Actinomycin D

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Actinomycin D

A-1022
  • CAS: 50-76-0
  • Formula: C62H86N12O16
  • MW: 1255.42
  • Appearance: Red to Red-orange crystalline powder
  • Purity: 98%

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Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria. Actinomycin D was the first antibiotic shown to have anti-cancer activity.

Actinomycin is a clear, yellow liquid administered intravenously and most commonly used in the treatment of a variety of cancers. It is also used as a radiosensitizer in adjunct to radiotherapies since it can increase the radiosensitivity of tumor cells, by inhibiting repair of sublethal radiation damage and, delay the onset of the compensatory hyperplasia that occurs following irradiation.

In cell biology, actinomycin D is shown to have the ability to inhibit transcription, this occurs by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA polymerase. 

 

Additional Information

SynonymsActinomycin IV; Actinomycin C1; Dactinomycin; Cosmegen; Meractinomycin; NCI C04682; NSC 3053; Oncostatin K
Product #A-1022
CAS #50-76-0
Chemical Name8-AMINO-N-(2-AMINO-4,6-DIMETHYL-3-OXO-PHENOXAZIN-1-YL)CARBONYL-N'-[8-AMINO-4,6-DIMETHYL-7-OXO-9-[[3,6,10-TRIMETHYL-7,14-BIS(1-METHYLETHYL)-2,5,8,12,15-PENTAOXO-9-OXA-3,6,13,16-TETRAZABICYCLO[14.3.0]NONADEC-11-YL]CARBAMOYL]PHENOXAZIN-1-YL]CARBONYL-4,6-DIME
FormulaC62H86N12O16
MW1255.42
AppearanceRed to Red-orange crystalline powder
Purity98%
SolubilityClear orange solution at 50 mg/ml DMSO or 10 mg/ml MeOH
Melting Point255 - 257°C
Storage TempStore desiccated at +4°C
Therapeutic AreaOncological Disorders
UseActinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes

Additional Information

Merck Index12.2867.1996
MDL NumberMFCD00005033
ChemACXX1005390-0
InChIInChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
SMILESC[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C

Additional Information

GHS Pictograms
RTECSAU1575000
UN #'SUN 3462
PACKING GROUPII
HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light

Additional Information

msds 1A-1022, Actinomycin D, SDS, diamond format.pdf
Certificate of Analysis 1A-1022, J1130.pdf
Certificate of Analysis 2A-1022, H1395.pdf
Certificate of Analysis 3A-1022, H1254A.pdf
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