AEBSF HCl

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AEBSF HCl

A-1018
  • CAS: 30827-99-7
  • Formula: C8H10FNO2S.HCl
  • MW: 239.69
  • Appearance: White to off-white powder
  • Purity: ≥97%

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Hazardous
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AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural.

AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits Dipeptidyl peptidase IV (DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.

 

 

Additional Information

SynonymsPefabloc SC; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Product #A-1018
CAS #30827-99-7
Chemical Name4-(2-Aminoethyl)-bezenesulfonylfluoride.HCl
FormulaC8H10FNO2S.HCl
MW239.69
AppearanceWhite to off-white powder
Purity≥97%
SolubilityClear colorless solution at 50mg/ml in H2O
Melting Point182-184 °C
Storage TempStore desiccated at -20°C, Protect from light & moisture!
UseAEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor

Additional Information

MDL NumberMFCD00132962
ChemACXX1086833-8
InChIInChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
SMILESc1cc(ccc1CCN)S(=O)(=O)F.Cl

Additional Information

GHS Pictograms
UN #'SUN 3261
PACKING GROUPII
HandlingStore in Tightly Sealed Vial. PROTECT FROM LIGHT & MOISTURE!

Additional Information

msds 1A-1018, AEBSF HCL, SDS, diamond format.pdf
Certificate of Analysis 1A-1018, J1257B.pdf
Certificate of Analysis 2A-1018, J1257A.pdf
Certificate of Analysis 3A-1018, J1257.pdf
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