Amphotericin B

A-1077
  • CAS: 1397-89-3
  • Formula: C47H73NO17
  • MW: 924.08
  • Appearance: Yellow or orange powder
  • Purity: ≥750 µg/mg (Assay)

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Description

Amphotericin B is a polyene anti-fungal antibiotic from Streptomyces nodosus that non-specifically induces loss of low molecular weight substances from cells. It binds to sterols and disrupts osmotic integrity of fungal membranes, forming pores which leads to the leakage of essential ions, causing cell death. 

 

Applications

Amphotericin B is used to control contamination from fungi, viruses, and protozoa.

 

Specifications

Beilstein Registry Number: 78342

EC Number: 215-742-2

Additional Information

SynonymsFungizone, Fungilin, Ampho-Moronal
Product #A-1077
CAS #1397-89-3
Chemical Name(1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10
FormulaC47H73NO17
MW924.08
AppearanceYellow or orange powder
Purity≥750 µg/mg (Assay)
SolubilityDMSO (35 mg/ml), DMF (3 mg/ml)
Storage Temp2-8°C
Therapeutic AreaAnti-fungal antibiotic
UseCell culture antibiotic

Additional Information

Merck Index13.590.2001
MDL NumberMFCD00877763
ChemACXX1004282-9
PubChecm ID5280965
InChIInChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
SMILESCC1C=CC=CC=CC=CC=CC=CC=CC(CC2C(C(CC(O2)(CC(CC(C(CCC(CC(CC(=O)OC(C(C1O)C)C)O)O)O)O)O)O)O)C(=O)O)OC3C(C(C(C(O3)C)O)N)O

Additional Information

GHS Pictograms
RTECSBU2625000
HandlingProtect from light and moisture

Additional Information

Certificate of Analysis 1A-1077, J1012C.pdf
Certificate of Analysis 2A-1077, J1012B.pdf
Certificate of Analysis 3A-1077, J1012A.pdf
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