Anisomycin | CAS 22862-76-6 | Anti-fungal antibiotic | AG Scientific

More Views

Anisomycin (Flagecidin)

A-1049
  • CAS: 22862-76-6
  • Formula: C14H19NO4
  • MW: 265.31
  • Appearance: White crystalline powder
  • Purity: >98% by HPLC

2

1

0

-

Hazardous
Add to Cart Bulk Inquiry

*IF >1GM, HAZARDOUS BOX FEE APPLIED*

Anisomycin is an antibiotic produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome. It also increases the phosphorylation of p70 S6 kinase α.

Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is used in Martin-Lewis Medium to inhibit Candida Albicans and aid in the identification of N.gonorrhea. Anisomycin or Flagecidin is also an anti-protozoal agent.

Novel natural killer cell-mediated cancer immunotherapeutic activity of anisomycin against hepatocellular carcinoma cells (HCC)1.

Anisomycin Activates Utrophin Upregulation Through a p38 Signaling Pathway. Regulating the dystrophin paralog utrophin in Duchenne muscular dystrophy (DMD) mouse models is a promising therapeutic strategy2.

Additional Information

SynonymsFlagecidin, SA 3097C1, PA 106, Anhydroscopin A, NSC 76712, (2S,3R,4R)-2-(4-methoxybenzyl)-4-hydroxypyrrolidin-3-yl acetate
Product #A-1049
CAS #22862-76-6
Chemical Name2-[(4-METHOXYPHENYL)METHYL]-3,4-PYRROLIDINEDIOL 3-ACETATE
FormulaC14H19NO4
MW265.31
AppearanceWhite crystalline powder
Purity>98% by HPLC
SolubilitySoluble in DMSO
Melting Point139-142°C
Storage TempStore desiccated at +4° C. PROTECT FROM LIGHT & MOISTURE! WARNING: VERY TOXIC!
Therapeutic AreaPsychological Disorders, Infectious Diseases

Additional Information

Merck Index13.673.2001
MDL NumberMFCD00077650
ChemACXX1000859-4
InChIInChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1
SMILESCC(=O)O[C@H]1[C@@H](CN[C@H]1Cc2ccc(cc2)OC)O

Additional Information

GHS Pictograms
RTECSBZ9800000
UN #'SUN 2811
PACKING GROUPIII
HAZARD CLASS6.1 Toxic
HandlingWarning.Toxic.

Additional Information

msds 1A-1049, Anisomycin, SDS, diamond format.pdf
Certificate of Analysis 1A-1049, J1289.pdf
Certificate of Analysis 2A-1049, H1392B.pdf
Certificate of Analysis 3A-1049, H1392A.pdf
E-Brochure Fermentation
Close pop-up box

Personal Information

* Required Fields

Additional Information

No Items Found

Newsletter

Got Questions? We have Answers!

Our team of experts are standing by to help you in every possible way.

Real People, Real Time, Rapid Response

Chip Lindgren

Founder/CEO

Ken Smith

Operations

Kyle Anderson

Procurement & Business Development

Skyler King

Customer Service

 

Nicole Tran

Customer Service

 

Casey Kennedy

Marketing

 

 

 

 

 

BULK ENQUIRY FORM

* Required Fields

*
*
*
*
*
*Bulk OEM Multiple Catalog Custom Other
Prod#CAS#*PRODUCT NAMEGrade*Size*QtyTime Frame

Custom magento captcha module from Outsource Online