(-)-Arctiin, Arctium lappa

A-1306
  • CAS: 20362-31-6
  • Formula: C27H34O11
  • MW: 534.6
  • Appearance: White to off-white Solid
  • Purity: 95% by HPLC

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Lignan derivative with anti-tumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV Type-I Integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor and Ca2+.

Additional Information

SynonymsArctigenin-4-glucoside
Product #A-1306
CAS #20362-31-6
Chemical Name(3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]-3-[[4-(β-D-glucopyranosyloxy)-3-methoxyphenyl]methyl]dihydro-2(3H)-furanone
FormulaC27H34O11
MW534.6
AppearanceWhite to off-white Solid
Purity95% by HPLC
SolubilitySoluble in DMSO (5mg/ml); sparingly soluble in water.
Storage Temp-20°C
Therapeutic AreaOncological Disorders
UseArctiin has shown to be a suppressor of cyclin D1 protein expression in multiple types of human tumor cells, such as osteosarcoma, lung, colorectal, cervical, breast, melanoma, and prostate cancer

Additional Information

MDL NumberMFCD00870630
ChemACXX1536500-9
InChIInChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1
SMILESCOc1ccc(cc1OC)C[C@H]2COC(=O)[C@@H]2Cc3ccc(c(c3)OC)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O

Additional Information

GHS Pictograms
HandlingStore in Tightly sealed Vial Protect from Light

Additional Information

Certificate of Analysis 1A-1306_A-1306,_B1066.pdf
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