11011-38-4
792
C43H69NO12
Solubility: Soluble in DMSO.
-20°C
Description
Ascomycin is an analog of FK506 with potent immunosuppressive antibiotic properties. It is an intensive calcium-dependent serine/threonine protein phosphatase inhibitor.
Ascomycin suppresses T-cell proliferation through binding to calcineurin (CaN) and interferes with dephosphorylation of various substrates. The mechanism downregulates production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.
It has known anticonvulsant activity in rat models. Because of CaN-mediated regulation of gamma aminobutyric acid (GABA) and glutamate receptor channels, ascomycin is related to neuronal cytoskeleton and dendritic spine morphology and inflammatory responses in gila cells. It blocks signaling pathways in astrocytes and changes the pattern of cytokine and neurotrophin gene expression.
Isolated from Streptomyces hygroscopicus var ascomyceticus.
Applications
• Immunosuppressive antibiotic
• Used for inflammatory skin
• Neuronal disease study
Specifications
• EC Number: 435-850-5
References
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
