Bafilomycin B1 | CAS 88899-56-3 | Inhibits  H+-ATPases natural extract

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Bafilomycin B1

B-1185
  • CAS: 88899-56-3
  • Formula: C44H65NO13
  • MW: 816
  • Appearance: White to Pale Yellow Powder
  • Purity: 95%

4

1

0

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A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase. Refer to B-1183 for Bafilomycin A1. Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney. Bafilomycin B1 has demonstrated that 4-Hydroxytamoxifen Induces Autophagic Death through K-Ras Degradation. Abnormal accumulation of undigested macromolecules, often disease-specific, is a major feature of lysosomal and neurodegenerative disease and is frequently attributed to defective autophagy.

Additional Information

Product #B-1185
CAS #88899-56-3
Chemical Name[2-HYDROXY-2-[3-HYDROXY-4-[(3Z,5E,11E,13Z)-9-HYDROXY-2,14-DIMETHOXY-6,8,10,12-TETRAMETHYL-15-OXO-16-OXA-1-YL]PENTAN-2-YL]-5-METHYL-6-PROPAN-2-YLOXAN-4-YL] (E)-4-[(2-HYDROXY-5-OXOCYCLOPENTEN-1-YL)AMINO]-4-OXOBUT-2-ENOATE
FormulaC44H65NO13
MW816
AppearanceWhite to Pale Yellow Powder
Purity95%
SolubilitySoluble in ethanol, methanol, DMF or DMSO
Storage Temp-20°C
UseBafilomycin B1 is a toxic macrolide antibiotic used to study cell processes

Additional Information

MDL NumberMFCD00242671
ChemACXX1097343-6
InChIInChI=1S/C44H65NO13/c1-23(2)41-28(7)35(56-37(49)18-17-36(48)45-38-31(46)15-16-32(38)47)22-44(53,58-41)30(9)40(51)29(8)42-33(54-10)14-12-13-24(3)19-26(5)39(50)27(6)20-25(4)21-34(55-11)43(52)57-42/h12-14,17-18,20-21,23,26-30,33,35,39-42,46,50-51,53H,15-16,19,22H2,1-11H3,(H,45,48)/b14-12-,18-17+,24-13+,25-20+,34-21-
SMILESCC1C/C(=C/C=CC(C(OC(=O)/C(=C/C(=C/C(C1O)C)/C)/OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)/C=C/C(=O)NC3=C(CCC3=O)O)O)O)OC)/C

Additional Information

GHS Pictograms
RTECSNG8841000
HandlingWarning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Light

Additional Information

Certificate of Analysis 1B-1185, G1086A.pdf
Certificate of Analysis 2B-1185, G1086.pdf
Certificate of Analysis 3B-1185_B-1185,_B1676.pdf
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