Bestatin HCl

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Bestatin HCl B-1075
  • CAS: 65391-42-6
  • Formula: C16H24N2O4.HCl
  • MW: 344.8
  • Appearance: White Solid
  • Purity: 98%

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Bestatin is a competitive, reversible protease inhibitor derived from Streptomyces olivoreticuli. Inhibits aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

It is being studied for use in the treatment of acute myelocytic leukemia.

Additional Information

Synonyms leucine aminopeptidase, aminopeptidase B
Product # B-1075
CAS # 65391-42-6
Chemical Name (2S)-2-[[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]AMINO]-4-METHYLPENTANOIC ACID HYDROCHLORIDE
Formula C16H24N2O4.HCl
MW 344.8
Appearance White Solid
Purity 98%
Solubility Soluble in Methanol and Acetic Acid
Melting Point 213-215°C
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use An inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase use in cancer

Additional Information

MDL Number MFCD00058004
ChemACX X1087674-3
InChI InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILES CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl

Additional Information

Handling Store in Tightly Sealed Vial Protect from Light

Additional Information

msds 1 B-1075, SDS.pdf
Certificate of Analysis 1 B-1075, H1276.pdf
Certificate of Analysis 2 B-1075, H1214B.pdf
Certificate of Analysis 3 B-1075, H1214A.pdf
E-Brochure Bestatin Inhibitor

Additional Information

Citations Synaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation

Additional Information

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