Bestatin HCl | CAS 65391-42-6 | Inhibitors | AG Scientific, Inc.

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Bestatin HCl

B-1075
  • CAS: 65391-42-6
  • Formula: C16H24N2O4 • HCl
  • MW: 344.8 Da
  • Appearance: White powder
  • Purity: ≥98%

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Bestatin is a competitive, reversible protease inhibitor derived from Streptomyces olivoreticuli. It inhibits aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

It is being studied for use in the treatment of acute myelocytic leukemia.

Noradrenaline (NA) is involved in the intrinsic control of pain-inducing pro-nociceptive effects in the primary afferent nociceptors. Bestatin intensified the antinociceptive effects of low-dose of NA3.

Additional Information

SynonymsAminopeptidase inhibitor, leucine aminopeptidase, aminopeptidase B
Product #B-1075
CAS #65391-42-6
Chemical Name(2S,3R)-3-Amino-2-hydroxy-4- phenylbutanoyl]-L-leucine • HCl
FormulaC16H24N2O4 • HCl
MW344.8 Da
AppearanceWhite powder
Purity≥98%
SolubilityClear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.
Melting Point213-215°C
Storage TempStore desiccated at -20°C
Therapeutic AreaOncological disorders
UseAn inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase

Additional Information

MDL NumberMFCD00058004
ChemACXX1087674-3
InChIInChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILESCC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl

Additional Information

GHS Pictograms
HandlingStore in a tightly-sealed vial and protect from light.

Additional Information

msds 1B-1075, Bestatin HCl, SDS, diamond format.pdf
Certificate of Analysis 1B-1075, J1212B.pdf
Certificate of Analysis 2B-1075, J1212A.pdf
Certificate of Analysis 3B-1075, J1212.pdf
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