Bestatin HCl

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Bestatin HCl B-1075
  • CAS: 65391-42-6
  • Formula: C16H24N2O4.HCl
  • MW: 344.8
  • Appearance: White powder
  • Purity: ≥98%

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Bestatin is a competitive, reversible protease inhibitor derived from Streptomyces olivoreticuli. Inhibits aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.

It is being studied for use in the treatment of acute myelocytic leukemia.

Additional Information

Synonymsleucine aminopeptidase, aminopeptidase B
Product #B-1075
CAS #65391-42-6
Chemical Name(2S)-2-[[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]AMINO]-4-METHYLPENTANOIC ACID HYDROCHLORIDE
FormulaC16H24N2O4.HCl
MW344.8
AppearanceWhite powder
Purity≥98%
SolubilityClear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.
Melting Point213-215°C
Storage TempStore desiccated at -20°C. PROTECT FROM LIGHT!
Therapeutic AreaOncological Disorders
UseAn inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase use in cancer

Additional Information

MDL NumberMFCD00058004
ChemACXX1087674-3
InChIInChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILESCC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl

Additional Information

HandlingStore in Tightly Sealed Vial Protect from Light

Additional Information

msds 1B-1075, SDS.pdf
Certificate of Analysis 1B-1075, H1214E.pdf
Certificate of Analysis 2B-1075, H1214D.pdf
Certificate of Analysis 3B-1075, H1276.pdf
E-Brochure Bestatin Inhibitor

Additional Information

CitationsSynaptopodin couples epithelial contractility to α-actinin-4–dependent junction maturation

Additional Information

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