Blasticidin S HCl

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Blasticidin S HCl

B-1247
  • CAS: 3513-03-9
  • Formula: C17H26N8O5.HCl
  • MW: 458.9
  • Appearance: White Powder
  • Purity: ≥98.0%

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Blasticidin S.H.cl is an aminoacylnucleoside antibiotic isolated from Streptomyces griseochromogenes. It shows high efficacy against both eukaryotic and prokaryotic cells. Aside from its antimicrobial properties, blasticidin has displayed antiviral, antitumor, and antifungal properties and has been used as a selection agent. It has been used to select for cells containing the blsbsr, or BSD resistance gene as well as HEK293-T cells and HEK-D5 cells. Additionally, blasticidin is effective in preventing cell culture contamination and studying protein synthesis.

Blasticidin S.Hcl functions by inhibiting peptide bond formation at the ribosome. It blocks hydrolysis of peptidyl-tRNA due to the large ribosomal subunit's increased affinity for tRNA. Blasticidin S.Hcl has a longstanding application as a gene selection antibiotic and has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system. 

 

Additional Information

Product #B-1247
CAS #3513-03-9
Chemical Name(2S,3S,6R)-3-[[(3S)-3-AMINO-5-[CARBAMIMIDOYL(METHYL)AMINO]PENTANOYL]AMINO]-6-(4-AMINO-2-OXOPYRIMIDIN-1-YL)-3,6-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID HYDROCHLORIDE
FormulaC17H26N8O5.HCl
MW458.9
AppearanceWhite Powder
Purity≥98.0%
SolubilitySoluble in water. Clear and faint yellow solution at 5 mg/ml in water. Insoluble in organic solvents.
Melting Point218.0-225.0 °C
Storage TempStore desiccated at +4°C. Protect from moisture.Warning: Very Toxic!
UseAn antibiotic inhibiting protein synthesis

Additional Information

MDL NumberMFCD02091640
ChemACXX1339381-2
InChIInChI=1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H
SMILES[H]/N=C(N)/N(C)CCC(CC(=O)NC1C=CC(OC1C(=O)O)n2ccc(nc2=O)N)N.Cl

Additional Information

GHS Pictograms
UN #'SUN 2811
PACKING GROUPII
HandlingWarning.Toxic. Store in Tightly Sealed Vial Protect from moisture.

Additional Information

msds 1B-1247, Blasticidin S HCl, SDS, diamond format.pdf
Certificate of Analysis 1B-1247, J1268.pdf
Certificate of Analysis 2B-1247, H1272.pdf
Certificate of Analysis 3B-1247, H1252A.pdf
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