Calpain inhibitor I, CAS# 110044-82-1, Calpain Inhibitor I  is Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190nM), calpain II (C-1259)(Ki=150nM), cathepsin B, cathepsin L (Ki=0.5nM) and other neutral cysteine proteases

More Views

Calpain Inhibitor I, MG-101

P-1153
  • CAS: 110044-82-1
  • Formula: C20H37N3O4
  • MW: 383.54
  • Appearance: White solid
  • Purity: ≥ 95% by HPLC

0

0

0

0

Hazardous
Add to Cart Bulk Inquiry

Calpain Inhibitor I  is Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190nM), calpain II (C-1259)(Ki=150nM), cathepsin B, cathepsin L (Ki=0.5nM) and other neutral cysteine proteases. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.

Calpain Inhibitor I also stimulates HMG-CoA synthase transcription by inhibiting degradation of active SREBP-1 (sterol regulatory element-binding protein 1). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II).

Calpain Inhibitor I inhibits proteolytic degradation of IκBα and IκBß in RAW macrophages induced with LPS. It also prolong association of MHC class I molecules with the transporters associated with antigen processing.

Additional Information

SynonymsALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal, N-Acetyl-Leu-Leu-Norleu-al
Product #P-1153
CAS #110044-82-1
Chemical NameAc-Leu-Leu-Nle-CHO
FormulaC20H37N3O4
MW383.54
AppearanceWhite solid
Purity ≥ 95% by HPLC
SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/mL)
Storage Temp-20°C, Store in Tightly Sealed Vial. Protect from Light. Protect from Moisture.

Additional Information

Additional Information

GHS Pictograms

Additional Information

Certificate of Analysis 1P-1153, J1129.pdf
Certificate of Analysis 2P-1153, H1026.pdf
Certificate of Analysis 3P-1153, F1302.pdf
Close pop-up box

Personal Information

* Required Fields

Additional Information

CitationsKannan, Nivetha, and Vivian W. Tang. "Synaptopodin Couples Epithelial Contractility to a-Actinin-4-Dependent Junction Maturation." The Journal of Cell Biology, vol. 211, no. 2, 26 Oct. 2015, pp. 407-434., doi:10.1083/jcb.201412003.
Kannan, Nivetha, and Vivian W. Tang. "Myosin-1c promotes E-cadherin tension and force-dependent recruitment of a-actinin-4 to the epithelial cell junction." J Cell Sci (2018): jcs-211334.
Tian, Jing, Joseph L. Goldstein, and Michael S. Brown. "Insulin induction of SREBP-1c in rodent liver requires LXRa-C/EBPb complex." Proceedings of the National Academy of Sciences 113.29 (2016): 8182-8187.
Tian, Jing, et al. "BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver." eLife (2018): e36826.
Tang, Vivian W., and William M. Brieher. "a-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction." J Cell Biol 196.1 (2012): 115-130.
ReferenceActinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction, Vivian W. Tang and William M. Brieher, J. Cell Biol. Jan 2012. 196: 115 - 130
Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells, Jingying Sarah Zhang, William E. Kraus, and George A. Truskey. Am J Physiol Cell Physiol. Aug 2004. 287: C292 - C299.
FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions. Tang, V. W. and Brieher, W. M. J. Cell Biol. Dec 2013. 203: 815-833.

Additional Information

No Items Found

Newsletter

Got Questions? We have Answers!

Our team of experts are standing by to help you in every possible way.

Real People, Real Time, Rapid Response

Chip Lindgren

Founder/CEO

Ken Smith

Operations

Kyle Anderson

Procurement & Business Development

Skyler King

Customer Service

 

Nicole Tran

Customer Service

 

Casey Kennedy

Marketing

 

 

 

 

 

BULK ENQUIRY FORM

* Required Fields

*
*
*
*
*
*Bulk OEM Multiple Catalog Custom Other
Prod#CAS#*PRODUCT NAMEGrade*Size*QtyTime Frame

Custom magento captcha module from Outsource Online