6,7-Diepicastanospermine; 6-Epicastanospermine; NSC 625381; 1,6,7,8-Tetrahydroxyoctahydroindolizine
79831-76-8
189.2
C8H15NO4
DMSO, PBS (pH 7.2)
-20°C
A plant derivative Castanospermine is a tetrahydroxylated alkaloid isolated from the seeds of Castanospermum australe. It is a potent inhibitor of beta-glucosidase and also inhibits fungal beta-xylosidase. Studies have shown Castanospermine to be a potent inhibitor of beta-glucocerebrosidase when assayed with fibroblast extracts using either a fluorimetric or a radioactive assay.Castanospermine exhibits antiviral properties and prevents angiogenesis.
Castanospermine has also shown to inhibit the MHC recycling process and affect its secretion in HIV infection. conclusive evidence has been derived from studies that Castanospermine can lower viral expression, production and infection of CD4 cells, to inhibit HIV depletion. Therefore researchers have concluded that Castanospermine as an inhibitor of the MHC system.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
