Clarithromycin

C-2645
  • CAS: 81103-11-9
  • Formula: C38H69NO13
  • MW: 748 Da
  • Appearance: White solid
  • Purity: >98% by HPLC

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*Please inquire the availability for this product. Clarithromycin (6-methoxyerythromycin) is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.

Additional Information

Synonyms6-O-Methylerythromycin A
Product #C-2645
CAS #81103-11-9
FormulaC38H69NO13
MW748 Da
AppearanceWhite solid
Purity>98% by HPLC
SolubilitySoluble in ethanol (<1 mg>
Melting Point222-231 °C
Storage TempRoom temperature
Therapeutic AreaInfectious Diseases
UseClarithromycin has bacteriostatic action against gram-positive bacteria and some gram-negative bacteria

Additional Information

MDL NumberMFCD00865140
InChIInChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
SMILESCC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

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