clasto-Lactacystin-b-lactone, Synthetic

L-1055
  • CAS: 155975-72-7
  • Formula: C10H15NO4
  • MW: 213.2
  • Appearance: White Solid
  • Purity: >95%

Hazardous
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Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for clasto-lactacystin b-lactone. Parkin Directly Modulates 26S Proteasome Activity.ASK1 Negatively Regulates the 26 S Proteasome.Parkin Ubiquitinates and Promotes the Degradation of RanBP2.Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.

 

Additional Information

SynonymsOmualide
Product #L-1055
CAS #155975-72-7
Chemical Name1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
FormulaC10H15NO4
MW213.2
AppearanceWhite Solid
Purity>95%
SolubilitySoluble in Chloroform or DMSO. Moderately Soluble in Water.
Melting Point161.31 °C
Storage TempStore at -20°C. Stock solutions are stable for up to 1 month at -80°C.
UseEffect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii

Additional Information

MDL NumberMFCD01076526
ChemACXX1094109-2
InChIInChI=1S/C10H15NO4/c1-4(2)7-10(9(14)15-7)6(12)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10+/m1/s1
SMILESO=C1O[C@@H](C(C)C)[C@]12NC(=O)[C@@H]([C@@H]2O)C

Additional Information

UN #'SUN 2811
PACKING GROUPIII
HandlingStore in Tightly Sealed Vial, protect from Light Stock solutionsstable at -80°C 1 month.

Additional Information

Certificate of Analysis 1L-1055, H1070.pdf
Certificate of Analysis 2L-1055, C1343.pdf
Certificate of Analysis 3L-1055, B1250.pdf
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