γ-Secretase Inhibitor XXI; (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
209986-17-4
490.5
C27H24F2N4O3
DMSO
-20°C
Compound E is a cell-permeable, potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC= 0.3 nM for totalamyloid) and Notch processing. At higher concentrations (20-400 M), only weakly affects the presenilase activity.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
