*IF >1GM HAZARDOUS BOX FEE APPLIED*
Cycloheximide is an antibiotic active against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.
Cycloheximide’s longstanding application as a gene selection antibiotic has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system. A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families.
Cycloheximide is in stock. Call for bulk quotations, typical lead for subdivision, packing and shipping larger quantities is 7-14 days.
Research size order 100mg 250mg lead is shorter.
|Synonyms||Actidione, Naramycin A, NSC-185, U-4527, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide|
|Appearance||White or cream color powder|
|Solubility||Soluble in Chloroform, Ethanol and Methanol|
|Preparation||Store solutions at -20°C|
|Storage Temp||Store desiccated at +4°C|
|Therapeutic Area||Infectious diseases|
|Use||Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria.|
|UN #'S||UN 2811|
|Handling||Warning: Toxic. Wear gloves and mask when handling. Avoid contact by all means of exposure. Store in a tightly-sealed vial.|
|msds 1||C-1189, Cycloheximide, SDS, diamond format.pdf|
|Certificate of Analysis 1||C-1189, J1235.pdf|
|Certificate of Analysis 2||C-1189, J1000.pdf|
|Certificate of Analysis 3||C-1189, H1121.pdf|
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