Cycloheximide

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Cycloheximide C-1189
  • CAS: 66-81-9
  • Formula: C15H23NO4
  • MW: 281.35
  • Appearance: White or cream color powder.
  • Purity: ≥95.0%

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Hazardous
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Cycloheximide is an antibiotic active against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.

Cycloheximide’s longstanding application as a gene selection antibiotic has a powerful new role in Genome editing utilizing the CRISPR/Cas9 systemA Candida albicans CRISPR system permits genetic engineering of essential genes and gene families.

Cycloheximide is in stock. Call for bulk quotations, typical lead for subdivision, packing and shipping larger quantities is 7-14 days.
Research size order 100mg 250mg lead is shorter.

 

Additional Information

SynonymsActidione, Naramycin A, NSC-185, U-4527
Product #C-1189
CAS #66-81-9
Chemical Name4-[(2R)-2-[(1S,3S,5S)-3,5-DIMETHYL-2-OXOCYCLOHEXYL]-2-HYDROXYETHYL]PIPERIDINE-2,6-DIONE
FormulaC15H23NO4
MW281.35
AppearanceWhite or cream color powder.
Purity≥95.0%
SolubilitySoluble in Chloroform, Ethanol and Methanol.
PreparationStore solutions at -20°C
Storage TempStore desiccated at +4°C
Therapeutic AreaInfectious Diseases
UseCycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria

Additional Information

MDL NumberMFCD00082346
ChemACXX1006248-5
InChIInChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
SMILESC[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C

Additional Information

GHS Pictograms
RTECSMA4375000
UN #'SUN 2811
PACKING GROUPI
HandlingWarning.Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Store in Tightly Sealed Vial

Additional Information

msds 1C-1189, SDS.pdf
Certificate of Analysis 1C-1189, J1235.pdf
Certificate of Analysis 2C-1189, J1000.pdf
Certificate of Analysis 3C-1189, H1121.pdf
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