Cyclosporin A, Fusarium solani

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Cyclosporin A, Fusarium solani

C-1199
  • CAS: 59865-13-3
  • Formula: C62H111N11O12
  • MW: 1202.6
  • Appearance: White Powder
  • Purity: 98%

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Potent immunosuppressor. Inhibitor of the mitochondrial permeability transition pore (MPTP), preventing necrosis in several models. Isolated fromFusarium solani.Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells.The Influence of B-Cell Lymphoma 2 Protein, an Antiapoptotic Regulator of Mitochondrial Permeability Transition, on Isoflurane-Induced and Ischemic Postconditioning in Rabbits.Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.

Additional Information

SynonymsCiclosporin, Cyclosporin A, Ramihyphin A, Cyclosporine
Product #C-1199
CAS #59865-13-3
Chemical Name(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ETHYL-33-[(E,1R,2R)-1-HYDROXY-2-METHYL-HEX-4-ENYL]-1,4,7,10,12,15,19,25,28-NONAMETHYL-6,9,18,24-TETRAKIS(2-METHYLPROPYL)-3,21-DIPROPAN-2-YL-1,4,7,10,13,16,19,22,25,28,31-UNDECAZACYCLOTRITRIACONTANE-2,5,8,11,14,17,
FormulaC62H111N11O12
MW1202.6
AppearanceWhite Powder
Purity98%
SolubilitySoluble inDMSO (25mg/ml), methanol, 100% ethanol (25mg/ml), or acetone. Insoluble in water
Storage Temp-20°C
Therapeutic AreaAutoimmune Diseases
UseCyclosporine A is an immunosuppressant drug widely used in organ transplantation to prevent rejection

Additional Information

MDL NumberMFCD00274558
ChemACXX1005487-8
InChIInChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
SMILESCC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

Additional Information

GHS Pictograms
RTECSGZ4120000
HandlingWarning.Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Solutions store at -20°C 3months.

Additional Information

Certificate of Analysis 1C-1199, E1043.pdf
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