Cyclosporin C chemical structure | CAS 59787-61-0 | Potent Immunosuppressor | AG Scientific, Inc.

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Cyclosporin C

C-1664
  • CAS: 59787-61-0
  • Formula: C62H111N11O13
  • MW: 1218.61 Da
  • Appearance: White to off-white solid
  • Purity: 95%

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Description

Cyclosporin C is a natural and neutral, non-polar, cyclic group of oligopeptides with immunosuppressant and antifungal activity. Cyclosporin C is highly lipophilic and binds cyclophilin intracellular proteins, involved in protein folding.

Cyclosporin C shows strong anti-hepatitis C (HCV) activity toward HCV replicons.

 

Applications

• Immunosuppressant used to study cell-signaling in autoimmune diseases
• Treatment of autoimmune disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and psoriasis
• Antifungal
• Used prevent rejection of grafts post-transplant due to cytotoxic effects of T-cells

 

Additional Information

Synonyms7-L-Threonine-Cyclosporin A, Thr2-cyclosporine, Thr2-cyclosporin A, Cyclosporine C, (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Thr-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-), WF-3484
Product #C-1664
CAS #59787-61-0
Chemical NameCyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
FormulaC62H111N11O13
MW1218.61 Da
AppearanceWhite to off-white solid
Purity95%
SolubilitySoluble in 100% ethanol, acetone or ethyl acetate. Insoluble in water.
Storage Temp-20°C
Therapeutic AreaAutoimmune diseases
UseCyclosporin C is an immunosuppressive cyclic polypeptide drug commonly used post-transplant to prevent graft rejection from the cytotoxic effects of T-cells.

Additional Information

MDL NumberMFCD06410945
ChemACXX1407180-0
InChIInChI=1S/C62H111N11O13/c1-25-26-39(14)52(76)51-56(80)66-50(42(17)74)61(85)67(18)32-48(75)68(19)43(27-33(2)3)55(79)65-49(38(12)13)62(86)69(20)44(28-34(4)5)54(78)63-40(15)53(77)64-41(16)57(81)70(21)45(29-35(6)7)58(82)71(22)46(30-36(8)9)59(83)72(23)47(31-37(10)11)60(84)73(51)24/h25-26,33-47,49-52,74,76H,27-32H2,1-24H3,(H,63,78)(H,64,77)(H,65,79)(H,66,80)/b26-25+/t39-,40+,41-,42?,43-,44-,45+,46-,47+,49+,50-,51+,52+/m0/s1
SMILESC/C=C/[C@H](C)[C@H]([C@@H]1C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N([C@@H](C(=O)N([C@H](C(=O)N([C@@H](C(=O)N1C)CC(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)O)O

Additional Information

GHS Pictograms
HandlingToxic. May be carcinogenic. Read MSDS prior to handling. Handling by trained professionals only.

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