GSI-IX, LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
208255-80-5
432.5
C23H26F2N2O4
Soluble in 100% Ethanol, DMSO, or Dichloromethane
-20°C
Description
DAPT is a cell permeable inhibitor of γ-secretase (IC=115 nM for totalamyloid, IC=200 nM foramyloid 1-42). It does not inhibit presenilinase. DAPT antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stel cell-derived embryoid bodies independent of sonic hedgehog (Shh) signaling.
Not for human therapeutic use or for medicinal purposes. For research applications only.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
