Dextran sulfate is an anionic polymer of sulfated glucose and acts as an accelerant for nucleic acid hybridizations. Dextran sulfate accelerates hybridizations by excluding nucleic acids from the volume of solution containing the polymer, thus increasing the effective probe concentration.
In a model of irritable bowel syndrome (IBD) in mice, oral doses of dextran sulfate have been found to yield inflammation of the colon. The substance can also be used to induce varying models of IBD, including acute, chronic, and relapsing conditions.
For solution format, see product Dextran Sulfate, 50% Solution (D-2603).
• Nucleic acid hybridizations: accelerant for faster probe annealing
• Anti-coagulant properties due to ability to precipitate lipoproteins from plasma solutions
• Ribosomal isolations
• Free sulfate content: <0.02%
• RNase: not detected
• DNase: not detected
|Synonyms||Sodium dextran sulfate|
|Chemical Name||dextran, hydrogen sulfate, sodium salt|
|Appearance||White to off-white crystalline powder|
|Storage Temp||Room temperature|
|Use||Accelerant for nucleic acid hybridizations|
|Handling||Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.|
|msds 1||D-2571, Dextran Sulfate Sodium Salt, SDS, diamond format.pdf|
|Certificate of Analysis 1||D-2571, H1118D.pdf|
|Certificate of Analysis 2||D-2571, H1118C.pdf|
|Certificate of Analysis 3||D-2571, H1118B.pdf|
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