E-64

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E-64

E-2030
  • CAS: 66701-25-5
  • Formula: C15H27N5O5. 0.5 H2O
  • MW: 357.4
  • Appearance: White Powder
  • Purity: ≥99% by HPLC

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E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. It does not affect cysteine residues in other enzymes. E-64 acts by forming a thioether bond with thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin), but inhibits activation-induced programmed cell death and restores defective immune responses in HIV. Specific active site titrant.

E-64 inhibits calpain, papain, and cathepsin B, cathepsin L. The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation in Giardia lamblia.

E-64 reduces inflammation in cystic fibrosis patients. E-64 plays a role in stabilizing the cytoskeleton protein Synaptopodin (Synpo), as well as, steadying signal transducer and activator of transcription-3 (STAT3). Studies suggest the potential use of STAT3 inhibitors in therapy of glomerular diseases.

 

 

Additional Information

SynonymsL-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide, L-trans-Epoxysuccinyl-Leu-agmatine, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide
Product #E-2030
CAS #66701-25-5
Chemical Nametrans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat
FormulaC15H27N5O5. 0.5 H2O
MW357.4
AppearanceWhite Powder
Purity≥99% by HPLC
SolubilityUp to 20mg/ml in water, Up to 25mg/ml in DMSO
Storage TempStore Desiccated at -20°C. Protect from light..

Additional Information

MDL NumberMFCD00080261
ChemACXX1036521-8
InChIInChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
SMILESCC(C)C[C@@H](C(=O)NCCCCNC(=N)N)NC(=O)[C@@H]1[C@H](O1)C(=O)O

Additional Information

GHS Pictograms
RTECSRR0390000
HandlingUse only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.

Additional Information

msds 1E-2030, E-64, SDS, diamond format.pdf
Certificate of Analysis 1E-2030, J1210.pdf
Certificate of Analysis 2E-2030, J1209.pdf
Certificate of Analysis 3E-2030, J1060.pdf
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