E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. It does not affect cysteine residues in other enzymes. E-64 acts by forming a thioether bond with thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin), but inhibits activation-induced programmed cell death and restores defective immune responses in HIV. Specific active site titrant.
E-64 inhibits calpain, papain, and cathepsin B, cathepsin L. The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation in Giardia lamblia.
E-64 reduces inflammation in cystic fibrosis patients. E-64 plays a role in stabilizing the cytoskeleton protein Synaptopodin (Synpo), as well as, steadying signal transducer and activator of transcription-3 (STAT3). Studies suggest the potential use of STAT3 inhibitors in therapy of glomerular diseases.
|Synonyms||L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide, L-trans-Epoxysuccinyl-Leu-agmatine, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagmatine, trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide|
|Chemical Name||trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat|
|Formula||C15H27N5O5. 0.5 H2O|
|Purity||≥99% by HPLC|
|Solubility||Up to 20mg/ml in water, Up to 25mg/ml in DMSO|
|Storage Temp||Store Desiccated at -20°C. Protect from light..|
|Handling||Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.|
|msds 1||E-2030, E-64, SDS, diamond format.pdf|
|Certificate of Analysis 1||E-2030, J1210.pdf|
|Certificate of Analysis 2||E-2030, J1209.pdf|
|Certificate of Analysis 3||E-2030, J1060.pdf|
|No Items Found|