Elastatinal, an elastase inhibitor

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Elastatinal, an elastase inhibitor

E-2044
  • CAS: 51798-45-9
  • Formula: C21H36N8O7
  • MW: 512.56
  • Appearance: Yellow to off white powder

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Elastatinal is an elastase inhibitor and has exhibited the ability to inhibit poliovirus and rhinovirus 2A proteinases in vitro. Elastatinal is a tetrapeptide derivative with an aldehyde group which is essential for inhibitory activity. Additionally, it has no effect on DNA repair and UV-induced sister chromatid exchanges, and inhibits the cleavages found at Ala-Ala bonds in peptides that represent the capsid/nucleocapsid site. Elastatinal is an inhibitor of Neutrophil Elastase. In pancreatic tumors Elastatinal has demonstrated the ability to reduce the rate of degradation of endostatin, an angiogenesis inhibitor.

Additional Information

Product #E-2044
CAS #51798-45-9
Chemical Name(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide
FormulaC21H36N8O7
MW512.56
AppearanceYellow to off white powder
SolubilitySoluble in water upto 20mg/ml
Storage TempStore Desiccated at -20°C. Protect from light.
UseAn elastase inhibitor

Additional Information

MDL NumberMFCD00151180
ChemACXX1089720-8
InChIInChI=1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)
SMILESCC(C)CC(C(=O)O)NC(=O)NC(C1CCN=C(N1)N)C(=O)NC(CCC(=O)N)C(=O)NC(C)C=O

Additional Information

RTECSLZ9600000
HandlingKeep dry. Freeze upon arrival.

Additional Information

msds 1E-2044, Elastatinal SDS, diamond format.pdf
Certificate of Analysis 1E-2044, J1151.pdf
Certificate of Analysis 2E-2044, H1430.pdf
Certificate of Analysis 3E-2044, E1282F.pdf
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