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Polymyxin B Agarose 4B-CL (Endotoxin Affisorbent™), 10 mL

Price$ 261.25
  • SKU: E-3353-10ML
  • Pack Size: 10 ML
Quantity
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2-8°C


Endotoxin Affisorbent consists of immobilized polymyxin B on 4B-CL. The polymyxins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymyxin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide. The immobilized polymixin B gel is a stable affinity matrix that resists leaching of ligand into the valuable preparation.

Affisorbent Endotoxin Removing Gel can also be used to remove endotoxins from nucleic acid (DNA) samples.Polymyxin B-4B-CL is used in protein chromatography, affinity chromatography and specialty resins. Polymyxin B- 4B-CL has been used to study periodontitis and endodontic infections as well as obesity and type 2 diabetes.
 Polymyxin B- 4B-CL is also used for the removal of endotoxin levels in protein solutions, cell culture media, ascites.

 

Technical Specifications:

  • Ligand: Polymyxin B
  • Matrix: 4B-CL (crosslinked agarose beads, 4%)
  • Particle size range: 52 – 165 µm
  • Matrix activation: Cyanogen bromide
  • Attachment: Amino group
  • Binding capacity: 200 – 500 µg LPS from E. coli serotype 0128:B12
  • pH stability: 3 – 10
  • Supplied as slurry in 50% glycerol containing 0.02% sodium azide
  • Storage temp: 2 – 8 °C

0.1 lbs



Research or further manufacturing use only, not for food or drug use.

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