(-)-Epigallocatechin gallate

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(-)-Epigallocatechin gallate

E-2002
  • CAS: 989-51-5
  • Formula: C22H18O11
  • MW: 458.4
  • Appearance: Cream Colored Powder
  • Purity: 98%

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Polyphenolic constituent of green tea that possesses potent anti-tumor, anti-inflammatory and anti-oxidant properties. Antitumor reagent. Antioxidant. Protects cells from lipid peroxidation and DNA damage induced by reactive free radicals. Inhibits inducible nitric oxide synthase (iNOS; NOS II). Chemopreventive anticancer agent. Induces apoptosis in human cancer cell lines. Inhibits MAP kinase mediated signalling pathways. Inhibits angiogenesis. Inhibits telomerase and DNA methyltransferase. Anti-inflammatory agent.

Additional Information

SynonymsEGCG
Product #E-2002
CAS #989-51-5
Chemical Name(2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate)
FormulaC22H18O11
MW458.4
AppearanceCream Colored Powder
Purity98%
SolubilitySoluble in Water
Melting Point212 °C
Storage Temp+4°C
Therapeutic AreaOncological Disorders
UseAn inhibitor of Bcl-2 use in cancer.Antitumor reagent

Additional Information

Merck IndexMerck Index: 13.3557.2001
MDL NumberMFCD00075940
ChemACXX1089866-9
InChIInChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
SMILESc1c(cc(c(c1O)O)O)[C@@H]2[C@@H](Cc3c(cc(cc3O2)O)O)OC(=O)c4cc(c(c(c4)O)O)O

Additional Information

GHS Pictograms
RTECSKB5200000
HandlingStore in Tightly Sealed Vial Protect from Light

Additional Information

Certificate of Analysis 1E-2002_E-2002,_D1200.pdf
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