ETYA voltage gated Na+ channel current

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ETYA, eicosatetraynoic acid

E-2000
  • CAS: 1191-85-1
  • Formula: C20H24O2
  • MW: 296.5
  • Appearance: Off White to White Solid
  • Purity: ≥98%

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The peroxisome proliferator-activated receptor (PPAR)-α activator, 5,8,11,14-eicosatetraynoic acid (ETYA), is an arachidonic acid analog. It is reported to inhibit up-regulation of pro-inflammatory genes. Among the inflammatory chemokines elaborated, glial cell-derived CCL2/MCP-1 is crucial, it promotes the migration and recruitment of inflammatory cells, it is primarily responsible for the initiation and progression of inflammatory responses in neurodegenerative disease and also associated with a variety of disease, including atherosclerosis.

ETYA has an anti-inflammatory mechanism, by increasing HuR-mediated-MKP-1 mRNA stability that leads to the specific suppression of CCL2/MCP-1 during inflammatory processes. Studies have shown that ETYA increases MKP-1 expression through HuR at the post-transcriptional level in a receptor-independent manner. Thereby providing evidence that ETYA is a potential therapeutic modulator of inflammation. ETYA's influence on suppressing CCL2/MCP-1 expression is an emerging therapeutic strategy for the treatment of neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, and brain ischemia.

A recent research regarding upper aerodigestive cancer ( an aggressive malignancy) has revealed that PPARγ pathways would be a novel therapy for this cancer. ETYA is a PPARγ activator and results from this study have shown that it down regulates cell proliferation and has antineoplastic features.

 

    Additional Information

    SynonymsEicosatetraynoic acid; 5,8,11,14-Eicosatetraynoic acid
    Product #E-2000
    CAS #1191-85-1
    Chemical NameOctadehydroarachidonic acid, Eicosatetraynoic acid
    FormulaC20H24O2
    MW296.5
    AppearanceOff White to White Solid
    Purity≥98%
    SolubilitySoluble in ethanol, methanol, or DMSO.
    Storage Temp+4°C

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    Certificate of Analysis 1E-2000, H1195.pdf
    Certificate of Analysis 2E-2000, G1196A.pdf
    Certificate of Analysis 3E-2000, G1196.pdf
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