Filipin complex, anti-fungal agent

F-2427
  • CAS: 11078-21-0
  • Formula: C35H58O11 (for Flipin III)
  • MW: 654.8 Da
  • Appearance: Yellow solid
  • Purity: >95% by HPLC

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 Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, and disrupting the membrane integrity. Inhibits mitochondrial respiration.

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Additional Information

Product #F-2427
CAS #11078-21-0
FormulaC35H58O11 (for Flipin III)
MW654.8 Da
AppearanceYellow solid
Purity>95% by HPLC
Storage Temp-20°C
Therapeutic AreaInfectious Diseases
UseFilipin complex is a potent broad spectrum antifungal agent

Additional Information

MDL NumberMFCD00131073
InChIInChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
SMILESCCCCC[C@H]([C@@H]1[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@H](C[C@@H](/C(=C/C=C/C=C/C=C/C=C/[C@@H]([C@H](OC1=O)C)O)/C)O)O)O)O)O)O)O)O

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Certificate of Analysis 1F-2427, H1354.pdf
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