Forskolin

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Forskolin F-1026
  • CAS: 66575-29-9
  • Formula: C22H34O7
  • MW: 410.5
  • Appearance: White crystalline solid
  • Purity: >99%

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Forskolin is an extract from the root of Coleus Forskohlii.  C. Forskholii, is a member of themint family of plants. Forskolin acts directly on adenylate cyclase, an enzyme that activates the synthesis of cyclic adenosine monophosphate (cAMP) in the cell. cAMP promotes the breakdown of stored fats in animal and human fat cells. In vitro and animals studies have shown forskolin and its derivative can inhibit cell proliferation, and induce cell cycle arrest and apoptosis in human gastric cancer cells. Forskolin was also found to inhibit melanoma cell-induced platelet aggregation and reduce lung metastasis. Forskolin upregulates the expression of cytochrome P450 3A (CYP3A) family through the pregnane-X-receptor that regulates the CYP3A genes.

It is used for a variety of conditions, including cancer, obesity, glaucoma, asthma, and heart failure. Small clinical studies suggest that forskolin can benefit obese men in weight management. When applied on the skin of mice, forskolin can stimulate the production of melanin in the absence of ultraviolet light. It has been proposed for use in sunless tanning lotions to reduce the risk of skin cancer by decreasing exposure to sun.

Additional Information

Synonyms Colforsin, Coleonol
Product # F-1026
CAS # 66575-29-9
Chemical Name 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, 7-Deacetyl-7-[O-(N-methylpiperazino)-g-butyryl]-, Dihydrochloride
Formula C22H34O7
MW 410.5
Appearance White crystalline solid
Purity >99%
Solubility Aqueous buffers or H2O
Storage Temp -20°C Long Term Storage.
Therapeutic Area Cardiological Disorders
Use An adenylate cyclase activator and MAP kinase inhibitor use a vasodilator and hypotensive agent

Additional Information

Merck Index Merck Index: 13.2500.2001
MDL Number MFCD00082317
ChemACX X1009715-3
InChI InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
SMILES CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O

Additional Information

GHS Pictograms
RTECS QL6150000
Handling Store in Tightly Sealed Vial

Additional Information

msds 1 F-1026, SDS.pdf
Certificate of Analysis 1 F-1026, H1258.pdf
Certificate of Analysis 2 F-1026, E1093O.pdf
Certificate of Analysis 3 F-1026, E1093N.pdf

Additional Information

Citations Hydrogen sulfide decreases ÃÂÂÂÂÂÂÂÂÂÂÃ

Additional Information

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