G-418 Sulfate Solution | CAS 108321-42-2 | Antibiotics | AG Scientific, Inc.

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G-418 Sulfate Solution, Sterile-Filtered

  • CAS: 108321-42-2
  • Formula: C20H40O10N4 • 2H2SO4
  • MW: 692.7 Da
  • Appearance: Clear and colorless solution
  • Purity: ≥90% (TLC)




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*AG Scientific's G-418 sulfate solution is a sterile filterate solution.*

G-418 sulfate, also known as geneticin, is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is commonly used in plant and mammalian cell culture as a selectable marker. G418 disulfate is freely soluble in water. Bacteria and algae require 5 µg/ml or less while animal cells may require 300-500 µg/ml.  It functions by causing a chain of nonsense mutations during translation, ultimately resulting in inhibition of polypeptide synthesis and protein elongation.

Resistance to G-418 is conferred through the nptll gene in plant cells and the neo gene in mammalian cells, which encode aminoglycoside 3'-phosphotransferase. For gene selection applications, a kill curve can be made to determine the minimum effective G418 concentration to kill non-resistant cells. G418 longstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system.

 Purity data is for a concentration of 50mg/ml active.


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SynonymsGeneticin solution, Glycoside-418 solution, Antibiotic G418 solution
Product #G-1035
CAS #108321-42-2
Chemical Name(2R,3S,4R,5R,6S)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-2-hydroxycyclohexyl]oxy- 2-(1-hydroxyethyl)oxane-3,4-diol
FormulaC20H40O10N4 • 2H2SO4
MW692.7 Da
AppearanceClear and colorless solution
Purity≥90% (TLC)
Storage TempStore at 4°C
UseAn antibiotic with potent antiparasitic and antiamoebic activity

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GHS Pictograms
HandlingProtect from light!

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msds 1G-1033, G-418 . sulfate, SDS, diamond format.pdf
Certificate of Analysis 1G-1035, H1291.pdf
Certificate of Analysis 2G-1035, G1274.pdf
Certificate of Analysis 3G-1035, F1294E.pdf
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Alpha 7 beta 2 Nicotinic Acetylcholine Receptors Assemble, Function, and Are Activated Primarily via Their alpha7 - alpha7 Interfaces, Teresa A. Murray, Daniel Bertrand, Roger L. Papke, Andrew A. George, Rigo Pantoja, Rahul Srinivasan, Qiang Liu, Jie Wu, Paul Whiteaker, Henry A. Lester and Ronald J. Lukas
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CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae

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