Geranylgeraniol CAS 24034-73-9 Inducer Of Apoptosis, Geranylgeraniol CAS 24034-73-9 protein isoprenylation-

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Geranylgeraniol

G-1013
  • CAS: 24034-73-9
  • Formula: C20H34O
  • MW: 290.5
  • Appearance: Colorless to light yellow oil / Pale yellow liquid
  • Purity: >90% (By GC)

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The diterpene Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. This compound has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. It has a role in the regulation of several cellular processes and in the control of inflammatory response to enzymatic regulation and response to oxidative stress.

The capacity of the isoprenoid, geranylgeraniol, to reverse inflammatory conditions appears to be highly relevant. Geranylgeraniol has the ability to restore the physiological cellular homeostasis, influencing the main factors of the mitochondrial damage (such as the components of the Bcl-2 family members, Bax and Bak). Geranylgeraniol downregulates the level of HMG CoA reductase and suppresses the growth of human liver, lung, ovary, pancreas, colon, stomach, and blood tumors.

Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. It has been found to induce apoptosis in HL-60 cells and also utilized for protein isoprenylation.

In cigarrette filter-based assays that measures certain chemicals to quantify the exposure to carcinogens and toxicants, geranylgeraniol is used as a surrogate Internal Standard (IS) or a positive control for the chemical Solanesol.

 

Additional Information

Synonyms3,7,11,15-Tetramethyl-2,6,10,14-hexadecatraen-1-ol, GG-OH, GGol, GGOH
Product #G-1013
CAS #24034-73-9
Chemical Name3,7,11,15-Tetramethyl-2,6,10,14-hexadecatraen-1-ol
FormulaC20H34O
MW290.5
AppearanceColorless to light yellow oil / Pale yellow liquid
Purity>90% (By GC)
Storage Temp-20°C Short term, -80°C recommended for long term.
UseGeranylgeraniol is a diterpene alcohol which plays a role in several important biological processes

Additional Information

MDL NumberMFCD00129083
ChemACXX1090846-4
InChIInChI=1S/C20H34O/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-21/h9,11,13,15,21H,6-8,10,12,14,16H2,1-5H3/b18-11+,19-13+,20-15+
SMILESCC(=CCC/C(=C/CC/C(=C/CC/C(=C/CO)/C)/C)/C)C

Additional Information

GHS Pictograms
HandlingStore in Tightly Sealed Vial

Additional Information

Certificate of Analysis 1G-1013, H1243.pdf
Certificate of Analysis 2G-1013, H1136A.pdf
Certificate of Analysis 3G-1013, G1183A.pdf
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