Hygromycin B Concentrated Solution | CAS 31282-04-9 | AG Scientific, inc.

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Hygromycin B, Concentrated Solution

H-1012-MU
  • CAS: 31282-04-9
  • Formula: C20H37N3O13
  • MW: 527.53 Da
  • Appearance: Light amber colored solution
  • Purity: 94.4%

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*AG Scientific's Hygromycin B solution is a sterile filterate solution in DI Water.*

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It is commonly used to study protein synthesis. Aside from its efficacy against bacteria, fungi, and higher eukaryotic cells, hygromycin B is also an antiviral agent inhibiting translation upon selectively entering cells made permeable due to viral infection. It works as a standard selection antibiotic in gene experiments, especially for selection of hygromycin resistance gene transformed cells.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. Hygromycin's longstanding application as a gene selection antibiotic, has a powerful new role in genome editing utilizing the CRISPR/CAS9 system.

*Attention! International shipping of this material can be subject to an additional hazardous shipping fee. An AG Scientific customer service representattive will contact you to confirm cost prior to shipping your international order.

Additional Information

SynonymsHygrovetine, Hygrovectine, D-streptamine
Product #H-1012-MU
CAS #31282-04-9
Chemical NameO-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
FormulaC20H37N3O13
MW527.53 Da
AppearanceLight amber colored solution
Purity94.4%
SolubilityWater
Storage TempStore at +4°C
Therapeutic AreaInfectious diseases
UseHygromycin B is an aminoglycoside antibiotic that kills bacteria and fungi.

Additional Information

Merck Index13.4878
MDL NumberMFCD06795479
ChemACXX1009739-3
InChIInChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1
SMILESCN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N

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GHS Pictograms
RTECSWK2130000
UN #'SUN 3462
PACKING GROUPI
HandlingWarning.Toxic. May be Carcinogenic. May be Teratogenic. Wear gloves/mask when handling product.

Additional Information

msds 1H-1012, Hygromycin B in DI , SDS, diamond format.pdf
Certificate of Analysis 1H-1012-MU, F1206D.pdf
Certificate of Analysis 2H-1012-MU, F1206C.pdf
Certificate of Analysis 3H-1012-MU, E1383D.pdf
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CitationsMahameed, Mohamed, and Boaz Tirosh. "Engineering CHO cells with an oncogenic KIT improves cells growth, resilience to stress, and productivity." Biotechnology and bioengineering 114.11 (2017): 2560-2570.
Kou, Yanjun, et al. "Structure-function analyses of the Pth11 receptor reveal an important role for CFEM motif and redox regulation in rice blast." New Phytologist 214.1 (2017): 330-342.
Qu, Baiyan, et al. "Droplet electroporation in microfluidics for efficient cell transformation with or without cell wall removal." Lab on a Chip 12.21 (2012): 4483-4488.
Kim, Ahreum, et al. "Protective vaccine efficacy of the complete form of PPE39 protein from Mycobacterium tuberculosis Beijing/K strain in mice." Clinical and Vaccine Immunology (2017): CVI-00219.
Kleinovink, E. W. J. The use of light in cancer immunotherapy. Diss. 2018.
Kujoth, Gregory C., et al. "CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis." mBio 9.2 (2018): e00412-18.
He, Hanjun, et al. "CELLULASE 6 and MANNANASE 7 affect cell differentiation and silique dehiscence." Plant physiology (2018): pp-01494.
Bergson, Shir, et al. "Fluorescent Tagging and Cellular Distribution of the Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Open Reading Frame 45 (ORF45) Tegument Protein." Journal of virology (2014): JVI-01091.
Samadder, Partha, et al. "Transcriptional and post-transcriptional enhancement of gene expression by the 5′ UTR intron of rice rubi3 gene in transgenic rice cells." Molecular Genetics and Genomics 279.4 (2008): 429-439.
Cokol, Murat, et al. "Systematic exploration of synergistic drug pairs." Molecular systems biology 7.1 (2011): 544.
ReferenceErgosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes, Katrin Krumpe, Idan Frumkin, et al., Mol. Biol. Cell. Oct 2012. 23: 3927 - 3935.
Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/beta-Catenin Pathway in Human Cancer- Yong Zhang, LingLing Toh, Peishan Lau and Xueying Wang
A Novel Downstream Regulatory Element Cooperates with the Silencing Machinery to Repress EPA1 Expression in Candida glabrata
Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors. Edith S.A. Hofinger et al. Glycobiology. 2007. 17: 444-453.
CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae - Mans R, van Rossum HM, Wijsman M, Backx A, Kuijpers NG, van den Broek M, Daran-Lapujade P, Pronk JT, van Maris AJ, Daran JM

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