Kainic Acid chemical structure | CAS 487-79-6 | Receptor Agonist | AG Scientific, Inc.

More Views

Kainic Acid (Natural)

  • CAS: 487-79-6
  • Formula: C10 H15 N O4
  • MW: 213.23
  • Appearance: White to Off white powder
  • Purity: >99% by HPLC




Add to Cart Bulk Inquiry

Kainic acid is a natural marine product originally isolated from the red marine alga D. Simplex. It is a potent central nervous system stimulant, acting through specific kainate receptors and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is utilised in primary neuronal cell cultures and acute brain slice preparations to study the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics.

Additional Information

Synonyms(-)-a-Kainic Acid
Product #K-1013
CAS #487-79-6
Chemical Name(2S,3S,4S)-3-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
FormulaC10 H15 N O4
AppearanceWhite to Off white powder
Purity>99% by HPLC
SolubilitySoluble in water (10 mg/mL)
Storage TempStore desiccated at room temperature
Therapeutic AreaNeurological disorders, Epilepsy
UseAn excitatory and excitotoxic glutamate-mimic kainate receptor agonist used in epilepsy

Additional Information

MDL NumberMFCD00077806

Additional Information

GHS Pictograms
HandlingStore in tightly-sealed vial. Protect from Moisture.

Additional Information

Certificate of Analysis 1K-1013, J1018.pdf
Certificate of Analysis 2K-1013, H1230A.pdf
Certificate of Analysis 3K-1013, H1230.pdf
Close pop-up box

Personal Information

* Required Fields

Additional Information

CitationsLlorente-Folch, Irene, et al. "L-lactate-mediated neuroprotection against glutamate-induced excitotoxicity requires ARALAR/AGC1." Journal of Neuroscience 36.16 (2016): 4443-4456.
Bhandare, Amol M., et al. "Seizure-induced sympathoexcitation is caused by activation of glutamatergic receptors in RVLM that also causes proarrhythmogenic changes mediated by PACAP and microglia in rats." Journal of Neuroscience 36.2 (2016): 506-517.
Jimenez-Pacheco, Alba, et al. "Transient P2X7 receptor antagonism produces lasting reductions in spontaneous seizures and gliosis in experimental temporal lobe epilepsy." Journal of Neuroscience 36.22 (2016): 5920-5932.
Liachenko, Serguei, et al. "Quantitative Assessment of MRI T 2 Response to Kainic Acid Neurotoxicity in Rats in vivo." Toxicological Sciences 146.1 (2015): 183-191.
Rowley, Shane, et al. "Mitochondrial respiration deficits driven by reactive oxygen species in experimental temporal lobe epilepsy." Neurobiology of disease 75 (2015): 151-158.
Zhao, Kunpeng, et al. "EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability." Journal of Neuroscience 33.20 (2013): 8861-8865.
Liang, Li-Ping, and Manisha Patel. "Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy." Redox biology 9 (2016): 45-49.
Gano, Lindsey B., et al. "Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy." Free Radical Biology and Medicine 123 (2018): 116-124.

Additional Information

No Items Found


Got Questions? We have Answers!

Our team of experts are standing by to help you in every possible way.

Real People, Real Time, Rapid Response

Chip Lindgren


Ken Smith


Kyle Anderson

Procurement & Business Development

Skyler King

Customer Service


Nicole Tran

Customer Service


Casey Kennedy








* Required Fields

*Bulk OEM Multiple Catalog Custom Other
Prod#CAS#*PRODUCT NAMEGrade*Size*QtyTime Frame

Custom magento captcha module from Outsource Online