Kanamycin Sulfate

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Kanamycin Sulfate

K-1022
  • CAS: 25389-94-0
  • Formula: C18H36N4O11•H2SO4
  • MW: 582.58 Da
  • Appearance: White to off-white crystalline powder
  • Purity: >95%

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Description

Kanamycin is an aminoglycosidic antibiotic that inhibits growth of gram-positive, gram-negative bacteria and mycoplasmas in cell culture. Kanamycin or kanamycin A is a major component of the antibiotic complex produced by certain strains of Streptomyces kanamyceticus. Kanamycin is supplied in two forms, a crystalline monosulfate monohydrate and a salt with a higher sulfate content. Kanamycin sulfate, which is sometimes referred to as “kanamycin bisulfate,” is obtained by adding sulfuric acid to a solution of the monosulfate and drying using a suitable procedure. Kanamycin sulfate binds to 30S ribosomes causing inhibition of bacterial protein synthesis.

 

Applications

Laboratory Use - resistance marker to grow plasmids of interest in competent bacterial cells.

Therapeutic Use - a second-line anti-tuberculosis drug.

 

Specifications

EC Number: 246-933-9

 

Additional Information

SynonymsKanamycin, Kanamycin A, Kanamycin A Sulfate, Kanamycin Sulfate Salt, Kanamycin monosulfate, Kanamycin acid sulfate, Kantrex, Ophtalmokalixan
Product #K-1022
CAS #25389-94-0
Chemical Name(3R,4S,6S)-2-(aminomethyl)-6-[(1R,4S,6R)-4,6-diamino-3-[(2R,4S,5R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
FormulaC18H36N4O11•H2SO4
MW582.58 Da
AppearanceWhite to off-white crystalline powder
Purity>95%
SolubilityWater
Melting Point250° C
Storage TempRoom temperature
Therapeutic AreaBacterial infections
UseAntibacterial and anti-tuberculosis agent

Additional Information

Merck Index13.5299.2001
MDL NumberMFCD00070253
ChemACXX1004299-4
PubChecm ID441374
InChIInChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
SMILESC1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O

Additional Information

GHS Pictograms

Additional Information

msds 1K-1022, Kanamycin sulfate, SDS, diamond format.pdf
Certificate of Analysis 1K-1022, H1116A.pdf
Certificate of Analysis 2K-1022, H1116.pdf
Certificate of Analysis 3K-1022, F1061D.pdf
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